Heart transplantation has become a standard therapy option for advanced heart failure. The
translation of heart transplantation from innovative experiments to long-term clinical success …

Heart transplantation (HTx) has become standard treatment for selected patients with end-
stage heart failure. Improvements in immunosuppressant, donor procurement, surgical …

The past year has been notable for the multiple celebrations and symposia around the globe
commemorating the first heart transplant ever performed by Dr. Christiaan Barnard at Groote …

Prezados colegas, Grandes avanços no diagnóstico, monitorização e tratamento da
Insuficiência Cardíaca (IC) foram observados nos últimos anos, com impactos reais na …

Background: Small studies have reported superiority of sirolimus (SRL) over calcineurin
inhibitor (CNI) in mitigating cardiac allograft vasculopathy (CAV) after heart transplantation …

Sirolimus (rapamycin) is a mammalian target of rapamycin (mTOR) inhibitor with
immunosuppressive, antiproliferative, antiangiogenic, antifungal, anti-restenosis and anti …

Background: We evaluated the diagnostic and prognostic value of quantification of
myocardial flow reserve (MFR) with positron emission tomography (PET) in orthotopic heart …

Background Data evaluating mTOR inhibitor use heart transplant (HT) patients comes from
relatively small studies and controversy exists regarding their specific role. We performed a …

Cardiac allograft vasculopathy (CAV) is a complex disease that remains a significant cause
of morbidity and mortality after orthotopic heart transplantation (OHT). Originating as a result …

Background Although everolimus potentially improves long-term heart transplantation (HTx)
outcomes, its early postoperative safety profile had raised concerns and needs optimization …