Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial pneumonia of unknown
cause with a median survival of only three years. Little is known about the mechanisms that …

At present, the etiology of idiopathic pulmonary fibrosis (IPF) remains elusive. Over the past
two decades, however, researchers have identified and described the underlying processes …

Fibrosis is a pathological result of a dysfunctional repair response to tissue injury and occurs
in a number of organs, including the lungs. Cellular metabolism regulates tissue repair and …

Background Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Repetitive
injury and reprogramming of the lung epithelium are thought to be critical drivers of disease …

Mitochondria regulate not only cell functions through energy generation but also aging-
associated cell phenotypes. Impaired mitochondrial structural and functional integrity …

Context Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in patients with type 2
diabetes mellitus (T2DM) and associated with significant morbidity and mortality. Thyroid …

Idiopathic pulmonary fibrosis (IPF) is an inexorably progressive lung disease of unknown
origin. Prognosis is poor, with limited treatment options available, and the median survival …

Increasing evidence highlights that senescence plays an important role in idiopathic
pulmonary fibrosis (IPF). This study delineates the specific contribution of mitochondria and …

Mitochondria play important roles in the maintenance of intracellular homeostasis; hence,
the quality control of mitochondria is crucial for cell fate determination. Mitochondria …

Background Nintedanib represents an antifibrotic compound able to slow down disease
progression of patients with idiopathic pulmonary fibrosis (IPF). Objective To investigate the …