Cell surface glycosylation is dynamic and often changes in response to cellular
differentiation under physiological or pathophysiological conditions. Altered glycosylation on …

Abstract Background The ST6Gal-I sialyltransferase is upregulated in numerous cancers,
and high expression of this enzyme correlates with poor patient prognosis in various …

Activation of the tumor necrosis factor receptor 1 (TNFR1) death receptor by TNF induces
either cell survival or cell death. However, the mechanisms mediating these distinct …

Introduction: The changes in glycan structures have been attributed to disease states for
several decades. The surface glycosylation pattern is a signature of physiological state of a …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor
prognosis. Gemcitabine, as a single agent or in combination therapy, remains the frontline …

Aberrant cell surface glycosylation is prevalent in tumor cells, and there is ample evidence
that glycans have functional roles in carcinogenesis. Nonetheless, many molecular details …

FOXP3 is an important X-linked suppressor of breast cancer. It is reported that FOXP3 is
usually mutant, absent, or cytoplasmic distribution in breast cancer cells, which increases …

Glycans represent a promising but only marginally accessed source of cancer markers. We
previously reported the development of a molecularly bottom-up approach to plasma and …

The receptive uterine endometrium specifically expresses certain glycosyltransferases, and
the corresponding oligosaccharides play important roles in accepting the embryo. The …

Neuroblastoma (NB) is the most common pediatric malignancy diagnosed before the first
birthday in which MYCN oncogene amplification is associated with poor prognosis. Although …