Anti‐tuberculosis (TB) drugs possess diverse abilities to penetrate the different host tissues
and cell types in which infecting Mycobacterium tuberculosis bacilli are located during active …

In therapeutic research, the safety and efficacy of pharmaceutical products are necessarily
tested on humans via clinical trials after an extensive and expensive preclinical …

This study evaluated coproporphyrin I (CPI) as a selective endogenous biomarker of
OATP1B‐mediated drug–drug interactions (DDIs) relative to clinical probe rosuvastatin …

Excess mineralocorticoid receptor (MR) activation promotes target organ dysfunction,
vascular injury and fibrosis. MR antagonists like eplerenone are used for treating heart …

Abstract Background and Objective Nonlinear mixed-effect models (NLMEMs) are
increasingly used for the analysis of longitudinal studies during drug development. When …

This work aimed to evaluate the once‐daily antituberculosis treatment as recommended by
the new Indian pediatric guidelines. Isoniazid, rifampin, and pyrazinamide concentration …

Mycophenolate mofetil (MMF), a prodrug of mycophenolic acid (MPA), is used to suppress
GvHD in patients undergoing hematopoietic stem cell transplantation (HCT). The purpose of …

Unlike drug dose optimisation, mathematical modelling has not been applied to vaccine
dose finding. We applied a novel Immunostimulation/Immunodynamic mathematical …

Background Physiological age-related changes in the haemostatic and coagulation systems
result in differing anticoagulant assay responses to standard anticoagulants. Therefore, we …

Aims Midazolam is the drug of choice for palliative sedation and is titrated to achieve the
desired level of sedation. A previous pharmacokinetic (PK) study showed that variability …