Drug permeation and metabolism in Mycobacterium tuberculosis: Prioritising local exposure as essential criterion in new TB drug development
Anti‐tuberculosis (TB) drugs possess diverse abilities to penetrate the different host tissues
and cell types in which infecting Mycobacterium tuberculosis bacilli are located during active …
and cell types in which infecting Mycobacterium tuberculosis bacilli are located during active …
Optimizing drug development in oncology by clinical trial simulation: Why and how?
J Gal, G Milano, JM Ferrero… - Briefings in …, 2018 - academic.oup.com
In therapeutic research, the safety and efficacy of pharmaceutical products are necessarily
tested on humans via clinical trials after an extensive and expensive preclinical …
tested on humans via clinical trials after an extensive and expensive preclinical …
Gaining mechanistic insight into coproporphyrin I as endogenous biomarker for OATP1B‐mediated drug–drug interactions using population pharmacokinetic …
S Barnett, K Ogungbenro, K Ménochet… - Clinical …, 2018 - Wiley Online Library
This study evaluated coproporphyrin I (CPI) as a selective endogenous biomarker of
OATP1B‐mediated drug–drug interactions (DDIs) relative to clinical probe rosuvastatin …
OATP1B‐mediated drug–drug interactions (DDIs) relative to clinical probe rosuvastatin …
Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion
Excess mineralocorticoid receptor (MR) activation promotes target organ dysfunction,
vascular injury and fibrosis. MR antagonists like eplerenone are used for treating heart …
vascular injury and fibrosis. MR antagonists like eplerenone are used for treating heart …
PFIM 4.0, an extended R program for design evaluation and optimization in nonlinear mixed-effect models
C Dumont, G Lestini, H Le Nagard, F Mentré… - Computer methods and …, 2018 - Elsevier
Abstract Background and Objective Nonlinear mixed-effect models (NLMEMs) are
increasingly used for the analysis of longitudinal studies during drug development. When …
increasingly used for the analysis of longitudinal studies during drug development. When …
Suboptimal Antituberculosis drug concentrations and outcomes in small and HIV‐Coinfected children in India: recommendations for dose modifications
B Guiastrennec, G Ramachandran… - Clinical …, 2018 - Wiley Online Library
This work aimed to evaluate the once‐daily antituberculosis treatment as recommended by
the new Indian pediatric guidelines. Isoniazid, rifampin, and pyrazinamide concentration …
the new Indian pediatric guidelines. Isoniazid, rifampin, and pyrazinamide concentration …
Population pharmacokinetics and pharmacodynamics of mycophenolic acid using the prospective data in patients undergoing hematopoietic stem cell transplantation
K Yoshimura, I Yano, T Yamamoto… - Bone marrow …, 2018 - nature.com
Mycophenolate mofetil (MMF), a prodrug of mycophenolic acid (MPA), is used to suppress
GvHD in patients undergoing hematopoietic stem cell transplantation (HCT). The purpose of …
GvHD in patients undergoing hematopoietic stem cell transplantation (HCT). The purpose of …
Using vaccine Immunostimulation/Immunodynamic modelling methods to inform vaccine dose decision-making
Unlike drug dose optimisation, mathematical modelling has not been applied to vaccine
dose finding. We applied a novel Immunostimulation/Immunodynamic mathematical …
dose finding. We applied a novel Immunostimulation/Immunodynamic mathematical …
Anticoagulant effects of dabigatran in paediatric patients compared with adults: combined data from three paediatric clinical trials
H Maas, S Gropper, F Huang, J Stangier… - Thrombosis and …, 2018 - thieme-connect.com
Background Physiological age-related changes in the haemostatic and coagulation systems
result in differing anticoagulant assay responses to standard anticoagulants. Therefore, we …
result in differing anticoagulant assay responses to standard anticoagulants. Therefore, we …
Population pharmacodynamic modelling of midazolam induced sedation in terminally ill adult patients
LG Franken, BCM de Winter… - British journal of …, 2018 - Wiley Online Library
Aims Midazolam is the drug of choice for palliative sedation and is titrated to achieve the
desired level of sedation. A previous pharmacokinetic (PK) study showed that variability …
desired level of sedation. A previous pharmacokinetic (PK) study showed that variability …