Splanchnic vein thrombosis in myeloproliferative neoplasms: treatment algorithm 2018

G Finazzi, V De Stefano, T Barbui - Blood Cancer Journal, 2018 - nature.com
Myeloproliferative neoplasms (MPNs) are a leading cause of splanchnic vein thrombosis
(SVT). SVT is observed in all MPNs and frequently affects young patients. Therapy should …

Prefibrotic myelofibrosis: treatment algorithm 2018

G Finazzi, AM Vannucchi, T Barbui - Blood cancer journal, 2018 - nature.com
Prefibrotic myelofibrosis (pre-PMF) is a distinct entity among chronic myeloproliferative
neoplasm diagnosed according to the revised 2016 WHO classification. The clinical picture …

Hydroxyurea prevents arterial and late venous thrombotic recurrences in patients with myeloproliferative neoplasms but fails in the splanchnic venous district. Pooled …

V De Stefano, E Rossi, A Carobbio, A Ghirardi… - Blood cancer …, 2018 - nature.com
We collected 1500 patients with myeloproliferative neoplasms (MPN) and arterial or venous
thrombosis (935/565), pooling three independent cohorts previously reported. Long-term …

Antithrombotic therapy for venous thromboembolism in myeloproliferative neoplasms

V De Stefano, G Finazzi, T Barbui - Blood cancer journal, 2018 - nature.com
In myeloproliferative neoplasms (MPNs) the incidence of venous thromboembolism (VTE) is
0.6–1.0 per 100 pt-years, and the rate of recurrence after VTE is 6.0–6.5 per 100 pt-yrs …

Ropeginterferon alpha-2b targets JAK2V617F-positive polycythemia vera cells in vitro and in vivo

E Verger, J Soret-Dulphy, N Maslah, L Roy, J Rey… - Blood cancer …, 2018 - nature.com
Polycythemia vera is characterized by the acquisition of the JAK2V617F mutation.
Recommended treatments include hydroxyurea and interferon-alpha. Several groups have …

The role of JAK2 inhibitors in MPNs 7 years after approval

F Passamonti, M Maffioli - Blood, The Journal of the American …, 2018 - ashpublications.org
Myeloproliferative neoplasms (MPNs) include essential thrombocythemia, polycythemia
vera (PV), and primary myelofibrosis (MF). Phenotype-driver mutations of JAK2, CALR, and …

Mutation landscape in patients with myelofibrosis receiving ruxolitinib or hydroxyurea

A Pacilli, G Rotunno, C Mannarelli, T Fanelli… - Blood Cancer …, 2018 - nature.com
Refractoriness to ruxolitinib in patients with myelofibrosis (MF) was associated with clonal
evolution; however, whether genetic instability is promoted by ruxolitinib remains unsettled …

What is pre‐fibrotic myelofibrosis and how should it be managed in 2018?

N Curto‐Garcia, JC Ianotto… - British journal of …, 2018 - Wiley Online Library
Summary The 2016 World Health Organization (WHO) classification for myeloproliferative
neoplasms (MPN) divided myelofibrosis (MF) into pre‐fibrotic (pre‐MF) and overt‐MF …

Different effect of hydroxyurea and phlebotomy on prevention of arterial and venous thrombosis in polycythemia vera

T Barbui, V De Stefano, A Ghirardi, A Masciulli… - Blood Cancer …, 2018 - nature.com
Clonal proliferation of hematopoietic precursors leading to progressive expansion of
myeloid cells with a predominant increase of red cells characterizes the hematological …

Post-ET and post-PV myelofibrosis: updates on a distinct prognosis from primary myelofibrosis

F Passamonti, B Mora, D Barraco, M Maffioli - Current hematologic …, 2018 - Springer
Abstract Purpose of Review The purpose of this review is to help doctors in the management
of patients with post-polycythemia (PPV) and post-essential thrombocythemia (PET) …