Combination anti-retroviral therapy (ART) has revolutionized the treatment and prevention of
HIV-1 infection. Taken daily, ART prevents and suppresses the infection. However, ART …

Antigenic mimicry is a fundamental tenet of structure-based vaccinology. Vaccine strategies
for the human immunodeficiency virus type 1 (HIV-1) focus on the mimicry of its envelope …

Broadly neutralizing antibodies (bNAbs) protect against HIV infection in non-human
primates and their efficacy may be enhanced through interaction with Fc receptors on …

Abstract Purpose of Review Pre-exposure prophylaxis (PrEP) is a potent HIV prevention
strategy, but uptake of daily oral PrEP remains low. This review covers PrEP agents currently …

Over the past decade, structures have been determined for broadly neutralizing antibodies
that recognize all major exposed surfaces of the prefusion-closed HIV-1-envelope (Env) …

A number of simian and simian human immunodeficiency viruses (SIV and SHIV,
respectively) have been used to assess the efficacy of HIV-1 vaccine strategies. Among …

Encouraging results from preclinical and clinical studies support the development of bNAbs
for prevention and a number of antibodies with exceptional breadth and potency are …

Genetically barcoded viral populations are powerful tools for evaluating the overall viral
population structure as well as assessing the dynamics and evolution of individual lineages …

ABSTRACT A vaccine regimen that elicits broadly neutralizing antibodies (bNAbs) is a major
goal in HIV-1 vaccine research. In this study, we assessed the immunogenicity of the …

Broadly neutralizing antibodies (bNAbs) against HIV-1 are under evaluation for both
prevention and therapy. HIV-1 sequence diversity observed in most HIV-infected individuals …