Flow chemistry: towards a more sustainable heterocyclic synthesis

P Brandão, M Pineiro… - European Journal of …, 2019 - Wiley Online Library
Flow Chemistry is a revolutionary field in Organic Chemistry. By changing the conventional
methods and apparatus applied in the chemical synthesis, flow chemistry emerges as a …

Development of new antituberculosis drugs among of 1, 3-and 1, 4-diazines. Highlights and perspectives

EV Verbitskiy, GL Rusinov, VN Charushin… - Russian Chemical …, 2019 - Springer
The properties of pyrimidine and pyrazine derivatives responsible for the existence of
antituberculosis activity are considered. Examples of synthesis and biological activity of the …

Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046

J Li, Y Wang, X Hao, S Li, J Jia, Y Guan, Z Peng, H Bi… - Molecules, 2019 - mdpi.com
A new pyrazine derivative, trypilepyrazinol (1), a new α-pyrone polyketide,(+)-
neocitreoviridin (2), and a new ergostane analogue, 3β-hydroxyergosta-8, 14, 24 (28)-trien …

Site-Selective C–H Alkylation of Diazine N-Oxides Enabled by Phosphonium Ylides

P Ghosh, NY Kwon, S Han, S Kim, SH Han… - Organic …, 2019 - ACS Publications
The synthesis of alkylated diazine derivatives is important for their practical utilization as
pharmaceuticals and for other purposes. Herein, we describe the metal-free site-selective C …

Promising 2, 6, 9-trisubstituted purine derivatives for anticancer compounds: Synthesis, 3D-QSAR, and preliminary biological assays

C O. Salas, AM Zarate, V Kryštof, J Mella… - International journal of …, 2019 - mdpi.com
We designed, synthesized, and evaluated novel 2, 6, 9-trisubstituted purine derivatives for
their prospective role as antitumor compounds. Using simple and efficient methodologies …

Streamlined Routes to Phenacyl Azides and 2, 5‐Diarylpyrazines Enabled by Deep Eutectic Solvents

P Vitale, L Cicco, F Messa, FM Perna… - European Journal of …, 2019 - Wiley Online Library
A Deep Eutectic Solvent like choline chloride/glycerol (1: 2 mol mol–1) proved to be an
effective, sustainable reaction medium to easily synthesize both phenacyl azides and …

Substantiation to structure-property of pyrazine-based compounds by undeniable impress of its different connectivities

M Bazargan, M Mirzaei, M Akbari - Journal of Molecular Structure, 2019 - Elsevier
In this review, we explain how pyrazine (hereafter as pz) leds to various structures spanning
from multicomponent molecular crystals to coordination polymers. An important factor in the …

Substituted N-(Pyrazin-2-yl)benzenesulfonamides; Synthesis, Anti-Infective Evaluation, Cytotoxicity, and In Silico Studies

G Bouz, M Juhás, L Pausas Otero… - Molecules, 2019 - mdpi.com
We prepared a series of substituted N-(pyrazin-2-yl) benzenesulfonamides as an attempt to
investigate the effect of different linkers connecting pyrazine to benzene cores on …

Synthesis and biological evaluation of novel 6-alkoxy-3-aryl-[1,2,4]triazolo[4,3-b][1,2,4,5] tetrazines

RJ Shi, ZZ Yang, YT Gao, WJ Cai… - Journal of Chemical …, 2019 - journals.sagepub.com
A series of 6-alkoxy-3-aryl-[1, 2, 4] triazolo [4, 3-b][1, 2, 4, 5] tetrazine derivatives is
synthesized and evaluated for their antitumor activities. These compounds exhibit potent …

[HTML][HTML] Design, synthesis, cytotoxicity and 3D-QSAR analysis of new 3, 6-disubstituted-1, 2, 4, 5-tetrazine derivatives as potential antitumor agents

A Canete-Molina, C Espinosa-Bustos… - Arabian Journal of …, 2019 - Elsevier
We synthesized two new series of 3-substituted-6-(2, 5-dimethylpyrazol-1-yl)-1, 2, 4, 5-
tetrazines and analysed them for a potential role as antitumor agents. Twenty-two …