Flow chemistry: towards a more sustainable heterocyclic synthesis
Flow Chemistry is a revolutionary field in Organic Chemistry. By changing the conventional
methods and apparatus applied in the chemical synthesis, flow chemistry emerges as a …
methods and apparatus applied in the chemical synthesis, flow chemistry emerges as a …
Development of new antituberculosis drugs among of 1, 3-and 1, 4-diazines. Highlights and perspectives
EV Verbitskiy, GL Rusinov, VN Charushin… - Russian Chemical …, 2019 - Springer
The properties of pyrimidine and pyrazine derivatives responsible for the existence of
antituberculosis activity are considered. Examples of synthesis and biological activity of the …
antituberculosis activity are considered. Examples of synthesis and biological activity of the …
Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046
J Li, Y Wang, X Hao, S Li, J Jia, Y Guan, Z Peng, H Bi… - Molecules, 2019 - mdpi.com
A new pyrazine derivative, trypilepyrazinol (1), a new α-pyrone polyketide,(+)-
neocitreoviridin (2), and a new ergostane analogue, 3β-hydroxyergosta-8, 14, 24 (28)-trien …
neocitreoviridin (2), and a new ergostane analogue, 3β-hydroxyergosta-8, 14, 24 (28)-trien …
Site-Selective C–H Alkylation of Diazine N-Oxides Enabled by Phosphonium Ylides
The synthesis of alkylated diazine derivatives is important for their practical utilization as
pharmaceuticals and for other purposes. Herein, we describe the metal-free site-selective C …
pharmaceuticals and for other purposes. Herein, we describe the metal-free site-selective C …
Promising 2, 6, 9-trisubstituted purine derivatives for anticancer compounds: Synthesis, 3D-QSAR, and preliminary biological assays
C O. Salas, AM Zarate, V Kryštof, J Mella… - International journal of …, 2019 - mdpi.com
We designed, synthesized, and evaluated novel 2, 6, 9-trisubstituted purine derivatives for
their prospective role as antitumor compounds. Using simple and efficient methodologies …
their prospective role as antitumor compounds. Using simple and efficient methodologies …
Streamlined Routes to Phenacyl Azides and 2, 5‐Diarylpyrazines Enabled by Deep Eutectic Solvents
P Vitale, L Cicco, F Messa, FM Perna… - European Journal of …, 2019 - Wiley Online Library
A Deep Eutectic Solvent like choline chloride/glycerol (1: 2 mol mol–1) proved to be an
effective, sustainable reaction medium to easily synthesize both phenacyl azides and …
effective, sustainable reaction medium to easily synthesize both phenacyl azides and …
Substantiation to structure-property of pyrazine-based compounds by undeniable impress of its different connectivities
In this review, we explain how pyrazine (hereafter as pz) leds to various structures spanning
from multicomponent molecular crystals to coordination polymers. An important factor in the …
from multicomponent molecular crystals to coordination polymers. An important factor in the …
Substituted N-(Pyrazin-2-yl)benzenesulfonamides; Synthesis, Anti-Infective Evaluation, Cytotoxicity, and In Silico Studies
G Bouz, M Juhás, L Pausas Otero… - Molecules, 2019 - mdpi.com
We prepared a series of substituted N-(pyrazin-2-yl) benzenesulfonamides as an attempt to
investigate the effect of different linkers connecting pyrazine to benzene cores on …
investigate the effect of different linkers connecting pyrazine to benzene cores on …
Synthesis and biological evaluation of novel 6-alkoxy-3-aryl-[1,2,4]triazolo[4,3-b][1,2,4,5] tetrazines
RJ Shi, ZZ Yang, YT Gao, WJ Cai… - Journal of Chemical …, 2019 - journals.sagepub.com
A series of 6-alkoxy-3-aryl-[1, 2, 4] triazolo [4, 3-b][1, 2, 4, 5] tetrazine derivatives is
synthesized and evaluated for their antitumor activities. These compounds exhibit potent …
synthesized and evaluated for their antitumor activities. These compounds exhibit potent …
[HTML][HTML] Design, synthesis, cytotoxicity and 3D-QSAR analysis of new 3, 6-disubstituted-1, 2, 4, 5-tetrazine derivatives as potential antitumor agents
A Canete-Molina, C Espinosa-Bustos… - Arabian Journal of …, 2019 - Elsevier
We synthesized two new series of 3-substituted-6-(2, 5-dimethylpyrazol-1-yl)-1, 2, 4, 5-
tetrazines and analysed them for a potential role as antitumor agents. Twenty-two …
tetrazines and analysed them for a potential role as antitumor agents. Twenty-two …