Next-generation of selective histone deacetylase inhibitors
Histone deacetylases (HDACs) are clinically validated epigenetic drug targets for cancer
treatment. HDACs inhibitors (HDACis) have been successfully applied against a series of …
treatment. HDACs inhibitors (HDACis) have been successfully applied against a series of …
Drugs targeting epigenetic modifications and plausible therapeutic strategies against colorectal cancer
S Patnaik, Anupriya - Frontiers in Pharmacology, 2019 - frontiersin.org
Genetic variations along with epigenetic modifications of DNA are involved in colorectal
cancer (CRC) development and progression. CRC is the fourth leading cause of cancer …
cancer (CRC) development and progression. CRC is the fourth leading cause of cancer …
Epigenetic regulation of TRAIL signaling: implication for cancer therapy
MIY Elmallah, O Micheau - Cancers, 2019 - mdpi.com
One of the main characteristics of carcinogenesis relies on genetic alterations in DNA and
epigenetic changes in histone and non-histone proteins. At the chromatin level, gene …
epigenetic changes in histone and non-histone proteins. At the chromatin level, gene …
Histone deacetylase inhibitors enhance cell killing and block interferon-beta synthesis elicited by infection with an oncolytic parainfluenza virus
CR Fox, GD Parks - Viruses, 2019 - mdpi.com
Previous results have shown that infection with the cytoplasmic-replicating parainfluenza
virus 5 mutant P/V-CPI-sensitizes cells to DNA damaging agents, resulting in the enhanced …
virus 5 mutant P/V-CPI-sensitizes cells to DNA damaging agents, resulting in the enhanced …
Impact of Hybrid-polar Histone Deacetylase Inhibitor m-Carboxycinnamic Acid bis-Hydroxyamide on Human Pancreatic Adenocarcinoma Cells
Background: Histone deacetylase inhibitors (HDACIs) have got immense importance as
promising drugs for cancer treatment as these inhibitors regulate cellular differentiation …
promising drugs for cancer treatment as these inhibitors regulate cellular differentiation …
The Role of Activating Transcription Factor 3 as a Regulator of DNA-Damaging Chemotherapy Cytotoxicity
MS Hasim - 2019 - ruor.uottawa.ca
DNA-damaging chemotherapeutics are a consistently employed for the treatment of cancer,
and are regularly part of first-line combination therapeutic regimens. However, these …
and are regularly part of first-line combination therapeutic regimens. However, these …
Docking analysis provide structural insights to design novel ligands that target PKM2 and HDC8 with potential use for cancer therapy
M Martinez-Archundia, B Colin-Astudillo… - Molecular …, 2019 - Taylor & Francis
The search of protein targets involved in cancer has gained importance in the later years
since cancer remains of the leading causes of death in the world. Histone deacetylase 8 …
since cancer remains of the leading causes of death in the world. Histone deacetylase 8 …
[图书][B] Guanidine-Based HDAC-Inhibitors as Anti-Cancer Agents
SH Sindi - 2019 - search.proquest.com
It is evident that epigenetics plays an important role in gene regulation. Consequently, any
disruption in epigenetic memory will manifest into gene expression and lead to long …
disruption in epigenetic memory will manifest into gene expression and lead to long …