BRAF mutations and the utility of RAF and MEK inhibitors in primary brain tumors

KC Schreck, SA Grossman, CA Pratilas - Cancers, 2019 - mdpi.com
BRAF mutations have been identified as targetable, oncogenic mutations in many cancers.
Given the paucity of treatments for primary brain tumors and the poor prognosis associated …

Advances in the management of craniopharyngioma in children and adults

M Jensterle, S Jazbinsek, R Bosnjak… - Radiology and …, 2019 - sciendo.com
Background. Childhood and adult-onset craniopharyngioma is a rare embryogenic tumor of
the sellar, suprasellar, and parasellar region. Survival rates are high; however, tumor …

Targeted treatment of papillary craniopharyngiomas harboring BRAF V600E mutations

TA Juratli, PS Jones, N Wang, M Subramanian… - Cancer, 2019 - Wiley Online Library
Papillary craniopharyngiomas (PCPs) are characterized by the presence of BRAF V600E
mutations, which are emerging as a useful guide for diagnosis and treatment decision …

The medical therapy of craniopharyngiomas: the way ahead

KI Alexandraki, GA Kaltsas, N Karavitaki… - The Journal of …, 2019 - academic.oup.com
Context Craniopharyngiomas, which are categorized as adamantinomatous (ACPs) or
papillary (PCPs), have traditionally been treated with surgery and/or radiotherapy, although …

A clinical rule for preoperative prediction of BRAF mutation status in craniopharyngiomas

S Fujio, TA Juratli, K Arita, H Hirano, Y Nagano… - …, 2019 - journals.lww.com
BACKGROUND Papillary craniopharyngiomas are characterized by BRAF V600E
mutations. Targeted therapy can elicit a dramatic radiographic regression of these tumors …

[HTML][HTML] Newly diagnosed papillary craniopharyngioma with BRAF V600E mutation treated with single-agent selective BRAF inhibitor dabrafenib: a case report

M Rao, M Bhattacharjee, S Shepard, S Hsu - Oncotarget, 2019 - ncbi.nlm.nih.gov
We report a case of a patient with newly diagnosed, locally extensive and cystic, suprasellar
papillary craniopharyngioma successfully treated with single-agent Dabrafenib. The patient …

Papillary craniopharyngioma in a 4-year-old girl with BRAF V600E mutation: a case report and review of the literature

R Borrill, E Cheesman, S Stivaros, ID Kamaly-Asl… - Child's Nervous …, 2019 - Springer
Introduction Craniopharyngiomas are one of the most frequently diagnosed hypothalamo-
pituitary tumors in childhood. The adamantinomatous histological subtype accounts for most …

Craniopharyngiomas and odontogenic tumors mimic normal odontogenesis and share genetic mutations, histopathologic features, and molecular pathways activation

CC Gomes, SF de Sousa, RS Gomez - Oral Surgery, Oral Medicine, Oral …, 2019 - Elsevier
Odontogenic tumors bear some histopathologic and molecular resemblance to
craniopharyngiomas. Specifically, adamantinomatous craniopharyngioma shares …

Adjuncts in glial tumor management: Optimizing strategy

D Muzumdar - International Journal of Neurooncology, 2019 - journals.lww.com
Surgery for low‑and high‑grade gliomas has evolved over the last two to three decades and
is still in evolution to achieve maximum resection rate. With the advances in radiation …

Überblick der Versorgungssituation von erwachsenen Kraniopharyngeom-Patienten in Deutschland

TK Kellner - 2019 - ediss.sub.uni-hamburg.de
Das Kraniopharyngeom ist ein seltener Tumor des zentralen Nervensystems, der
überwiegend im Kindesalter auftritt und in dieser Altersgruppe bereits ausführlich …