Highlights•The best servers based on “free” docking methods find acceptable models
among the top 10 predictions for around 40% of the targets.•Re-ranking the predictions by a …

A third of the genes in prokaryotic and eukaryotic genomes encode membrane proteins that
are either essential for signal transduction and solute transport or function as scaffold …

Protein–protein interactions (PPIs) play an important role in the different functions of cells,
but accurate prediction of the three-dimensional structures for PPIs is still a notoriously …

Cell surface receptors play a critical role in modulating intracellular signal transduction,
making them important drug targets. However, it remains challenging to develop a selective …

The lysosomal enzyme glucocerebrosidase-1 (GCase) catalyzes the cleavage of a major
glycolipid glucosylceramide into glucose and ceramide. The absence of fully functional …

Abstract Treatment of muscle-invasive bladder cancer remains a major clinical challenge.
Aberrant HGF/c-MET upregulation and activation is frequently observed in bladder cancer …

In eukaryotes, cellular respiration is driven by mitochondrial cytochrome c oxidase (CcO), an
enzyme complex that requires copper cofactors for its catalytic activity. Insertion of copper …

Citrus greening (huanglongbing) is the most destructive disease of citrus worldwide caused
by Candidatus Liberibacter asiaticus (CLA). Currently, no strategies have been developed to …

Interactions between nuclide acids (RNA/DNA) play important roles in many basic cellular
activities like transcription regulation, RNA processing, and protein synthesis. Therefore …

Hypoxic microenvironment deregulates metabolic homeostasis in cancer cells albeit the
underlying mechanisms involved in this process remain hitherto enigmatic. 14-3-3ζ/Yes …