Rad53-and Chk1-dependent DNA damage response pathways cooperatively promote fungal pathogenesis and modulate antifungal drug susceptibility
Living organisms are constantly exposed to DNA damage stress caused by endogenous
and exogenous events. Eukaryotic cells have evolutionarily conserved DNA damage …
and exogenous events. Eukaryotic cells have evolutionarily conserved DNA damage …
Srs2 helicase prevents the formation of toxic DNA damage during late prophase I of yeast meiosis
H Sasanuma, HSM Sakurai, Y Furihata, K Challa… - Chromosoma, 2019 - Springer
Proper repair of double-strand breaks (DSBs) is key to ensure proper chromosome
segregation. In this study, we found that the deletion of the SRS2 gene, which encodes a …
segregation. In this study, we found that the deletion of the SRS2 gene, which encodes a …
Tel1/ATM signaling to the checkpoint contributes to replicative senescence in the absence of telomerase
L Menin, CV Colombo, G Maestrini, MP Longhese… - Genetics, 2019 - academic.oup.com
Abstract Mecl/ATR and Tell/ATM trigger replicative senescence when telomeres become
critically short in the absence of telomerase, but how Tell/ATM promotes senescence is still …
critically short in the absence of telomerase, but how Tell/ATM promotes senescence is still …
[PDF][PDF] In Vivo High Content Analyses of Protein-protein Interactions at Budding Yeast Kinetochores Using a Wide-field Time-gated FLIM-based Platform OpenFLIM …
W Guo - 2019 - core.ac.uk
This thesis describes my work to develop and apply an automated fluorescence lifetime
imaging (FLIM) microscopy-based method for high-content analysis (HCA) of proteinprotein …
imaging (FLIM) microscopy-based method for high-content analysis (HCA) of proteinprotein …
DNA damage-specific effects of Tel1/ATM and γH2A/γH2AX on checkpoint signaling in Saccharomyces cerevisiae
DNA lesions trigger the activation of DNA damage checkpoints (DDCs) that stop cell cycle
progression and promote DNA damage repair. Saccharomyces cerevisiae Tel1 is a …
progression and promote DNA damage repair. Saccharomyces cerevisiae Tel1 is a …