Circulating Y-RNAs in extracellular vesicles and ribonucleoprotein complexes; implications for the immune system

TAP Driedonks, ENM Nolte-'t Hoen - Frontiers in immunology, 2019 - frontiersin.org
The exchange of extracellular vesicles (EV) between immune cells plays a role in various
immune regulatory processes. EV are nano-sized lipid bilayer-enclosed structures that …

The multitasking potential of alarmins and atypical chemokines

A Kapurniotu, O Gokce, J Bernhagen - Frontiers in medicine, 2019 - frontiersin.org
When the human genome was sequenced, it came as a surprise that it contains “only”
21,306 protein-coding genes. However, complexity and diversity are multiplied by …

Crystal structure of a Y-box binding protein 1 (YB-1)–RNA complex reveals key features and residues interacting with RNA

XJ Yang, H Zhu, SR Mu, WJ Wei, X Yuan… - Journal of Biological …, 2019 - ASBMB
The Y-box binding protein 1 (YB-1) is a member of the cold shock domain (CSD) protein
family and is recognized as an oncogenic factor in several solid tumors. By binding to RNA …

Why be one protein when you can affect many? The multiple roles of YB-1 in lung cancer and mesothelioma

TG Johnson, K Schelch, S Mehta, A Burgess… - Frontiers in cell and …, 2019 - frontiersin.org
Lung cancers and malignant pleural mesothelioma (MPM) have some of the worst 5-year
survival rates of all cancer types, primarily due to a lack of effective treatment options for …

Y-box binding protein 1 regulates ox-LDL mediated inflammatory responses and lipid uptake in macrophages

X Cao, N Zhu, L Li, Y Zhang, Y Chen, J Zhang… - Free Radical Biology …, 2019 - Elsevier
Aims Y-box protein 1 (YB1) is a key regulator of inflammatory mediators. However, the roles
of YB1 in oxidized low-density lipoprotein (ox-LDL)-induced macrophage inflammation and …

Serum Y-Box Binding Protein 1 (YBX-1) and interleukin 6 (IL-6) are associated with metastasis in breast cancer patients

CK Abd-Elaziz, NA Abd El Moneim… - Advances in Breast …, 2019 - ebooks.netkumar1.in
Objectives: The aim of this study was to assess the levels of Y-box binding protein 1 (YBX-1)
and interleukin 6 (IL-6) in the sera of metastatic and non-metastatic breast cancer patients …

Inhibitory Effect of Transcription Factor YB-1 in the Development of Signal from an Innate Immunity Receptor NOD2

LG Alekseeva, AG Laman… - Russian Journal of …, 2019 - Springer
It was shown that in the presence of the recombinant protein YB-1, the response of human
leukemic monocytes THP-1 to stimulation with muramylpeptide GMDP and LPS was …

Ингибиторный эффект фактора транскрипции YB-1 при формировании сигнала от NOD2-рецептора врожденного иммунитета

ЛГ Алексеева, АГ Ламан, АО Шепеляковская… - Биоорганическая …, 2019 - elibrary.ru
Установлено, что рекомбинантный фактор транскрипции YB-1 ингибирует ответ
лейкемических моноцитов человека линии ТНР-1 на стимуляцию N …

[图书][B] Y-Box Binding Proteins regulate CD8+ T cell differentiation and function

MT Mamroth - 2019 - search.proquest.com
CD8+ T cells are important for pathogen clearance and have many intrinsic and extrinsic
factors that can determine how they differentiate into effector and memory cells. The Y-box …

CRISPR/Cas9 genome editing for the generation of YB1 knockout human and insect cell lines for the production of recombinant Adeno-associated virus vectors

K Miah - 2019 - centaur.reading.ac.uk
The use of Adeno-associated viral (AAV) vectors for gene therapy has been most promising
because of their safety profile; however, current production methods limit desirable amounts …