What are the most important and treatable pathogenic mechanisms in C9orf72-FTD/ALS?
Model-based efforts to address this question are forging ahead at a blistering pace, often …

Microsatellite mutations involving the expansion of tri-, tetra-, penta-, or hexanucleotide
repeats cause more than 40 different neurological disorders. Although, traditionally, the …

Repeat expansions in the C9orf72 gene cause amyotrophic lateral sclerosis and
frontotemporal dementia characterized by dipeptide-repeat protein (DPR) inclusions. The …

More than 40 different neurological diseases are caused by microsatellite repeat
expansions. Since the discovery of repeat-associated non-AUG (RAN) translation by Zu et …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are
neurodegenerative disorders with overlapping pathomechanisms, neurobehavioral features …

The nuclear pore is the gatekeeper of nucleocytoplasmic transport and signaling through
which a vast flux of information is continuously exchanged between the nuclear and …

Hexanucleotide repeat expansions of variable size in C9orf72 are the most prevalent
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Sense and …

Frontotemporal dementia (FTD) encompasses a collection of clinically and pathologically
diverse neurological disorders. Clinical features of behavioural and language dysfunction …

A fundamental question regarding the etiology of amyotrophic lateral sclerosis (ALS) is
whether the various gene mutations associated with the disease converge on a single …

Many human diseases are associated with the expansion of repeat sequences within the
genes. It has become clear that expressed disease transcripts bearing such long repeats …