Cell migration is essential for physiological processes as diverse as development, immune
defence and wound healing. It is also a hallmark of cancer malignancy. Thousands of …

Cellular senescence is a cell state implicated in various physiological processes and a wide
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …

Abstract Exhausted CD8+ T (Tex) cells in chronic infections and cancer have limited effector
function, high co-expression of inhibitory receptors and extensive transcriptional changes …

The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …

The heterogeneity of small extracellular vesicles and presence of non-vesicular extracellular
matter have led to debate about contents and functional properties of exosomes. Here, we …

The clearance of surplus, broken, or dangerous components is key for maintaining cellular
homeostasis. The failure to remove protein aggregates, damaged organelles, or intracellular …

Cellular senescence is implicated in physiological and pathological processes spanning
development, wound healing, age-related decline in organ functions and cancer. Here, we …

The senescence-associated secretory phenotype (SASP) defines the ability of senescent
cells to express and secrete a variety of extracellular modulators that includes cytokines …

Across all branches of the immune system, the process of autophagy is fundamentally
important in cellular development, function and homeostasis. Strikingly, this evolutionarily …

Cancer is one of the leading causes of death across the world. Different environmental and
anthropogenic factors initiate mutations in different functional genes of growth factors and …