Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

With the availability of DNA-based molecular markers during early 1980s and that of
sophisticated statistical tools in late 1980s and later, it became possible to identify genomic …

Accurate prediction of an individual's phenotype from their DNA sequence is one of the great
promises of genomics and precision medicine. We extend a powerful individual-level data …

Several recent papers have reported strong signals of selection on European polygenic
height scores. These analyses used height effect estimates from the GIANT consortium and …

Visceral adipose tissue (VAT)—fat stored around the internal organs—has been suggested
as an independent risk factor for cardiovascular and metabolic disease,–, as well as all …

Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common
form of clonal mosaicism,,,–, yet our knowledge of the causes and consequences of this is …

It is estimated that 350 million individuals worldwide suffer from rare diseases, which are
predominantly caused by mutation in a single gene. The current molecular diagnostic rate is …

Background Few genetic studies that focus on moderate-to-severe asthma exist. We aimed
to identity novel genetic variants associated with moderate-to-severe asthma, see whether …

Body mass and body fat composition are of clinical interest due to their links to
cardiovascular-and metabolic diseases. Fat stored in the trunk has been suggested to be …

Complex traits and common diseases are extremely polygenic, their heritability spread
across thousands of loci. One possible explanation is that thousands of genes and loci have …