This article reviews genes and syndromes associated with predisposition to colorectal
cancer (CRC), with an overview of gene variant classification. We include updates on the …

Identifying individuals with hereditary syndromes allows for improved cancer surveillance,
risk reduction, and optimized management. Establishing criteria for assessment allows for …

Importance Since the discovery ofBRCA1andBRCA2, multiple high-and moderate-
penetrance genes have been reported as risk factors for hereditary breast cancer, ovarian …

Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is used to identify MMR
status: being diffusely positive (intact/retained nuclear staining) or showing loss of nuclear …

Currently, colorectal cancers accounted for the second‐highest number of cancer deaths in
the US. Hereditary syndromes, strong family history, and inflammatory bowel disease are all …

Purpose The aim of this study was to evaluate the Immunoscore (IS) methodology as a
prognostic marker of colorectal adenocarcinoma in Tunisian population. Tumor blocks were …

PURPOSE The current diagnostic testing algorithm for Lynch syndrome (LS) is complex and
often involves multiple follow-up germline and somatic tests. We aimed to describe the …

Purpose Biallelic pathogenic variants in the mismatch repair (MMR) genes cause a
recessive childhood cancer predisposition syndrome known as constitutional mismatch …

Background Type 2 diabetes mellitus and high total cholesterol and triglycerides are known
to be associated with increased colorectal cancer risk for the general population. These …

Lynch syndrome is a hereditary cancer syndrome caused by germline mutations in one of
several DNA mismatch repair genes. Lynch syndrome leads to an increased lifetime risk of …