Pheochromocytomas (PCCs) are rare neuroendocrine tumors. About 80% to 85% of these
cancers arise from chromaffin cells residing in the adrenal medulla. The remaining 15% to …

The adrenal medulla is composed predominantly of chromaffin cells producing and
secreting the catecholamines dopamine, norepinephrine, and epinephrine. Catecholamine …

Background Pheochromocytoma (PCC) and paraganglioma (PGL) are uncommon
neoplasms with high morbidity in advanced stages. Effective systemic treatments are limited …

Mitochondria are cellular organelles that control metabolic homeostasis and ATP
generation, but also play an important role in other processes, like cell death decisions and …

Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors that
show the highest heritability of all human neoplasms and represent a paradoxical example …

Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of rare malignancies,
mainly originating from hormone-secreting cells, which are widespread in human tissues …

Transformation of a normal cell to cancerous one is dependent on the accumulation of
several genetic and epigenetic alterations. One of the candidate driver genetic alterations …

Paragangliomas and Pheochromocytomas are rare, mostly benign neuroendocrine tumors,
which are embryologically derived from neural crest cells of the autonomic nervous system …

Abstract Context von Hippel-Lindau (VHL) disease, comprising renal cancer,
hemangioblastoma, and/or pheochromocytoma (PHEO), is caused by missense or …

The enzyme succinate dehydrogenase (SDH) functions in the citric acid cycle and loss of
function predisposes to the development of phaeochromocytoma/paraganglioma (PPGL) …