Abnormal placentation is considered as an underlying cause of various pregnancy
complications such as miscarriage, preeclampsia and intrauterine growth restriction, the …

In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

In mammals, the expression of a subset of microRNA (miRNA) genes is governed by
genomic imprinting, an epigenetic mechanism that confers monoallelic expression in a …

Preeclampsia is a multisystemic pregnancy disorder and a major cause of maternal and
neonatal morbidity and mortality worldwide. The exact pathophysiology of preeclampsia …

Single-cell gene expression analyses of mammalian tissues have uncovered profound
stage-specific molecular regulatory phenomena that have changed the understanding of …

Introduction There are considerable variations in villous morphology within a normal
placenta. However, whether there is a reproducible spatial pattern of variation in villous …

Pregnancy complications associated with chronic fetal hypoxia have been linked to the
development of adult cardiovascular disease in the offspring. Prenatal hypoxia has been …

Across mammalian species, solute exchange takes place in complex microvascular
networks. In the human placenta, the primary exchange units are terminal villi that contain …

Fetal growth restriction (FGR) is a complex disorder of human pregnancy that leads to poor
health outcomes in offspring. These range from immediate risks such as perinatal morbidity …

Preterm birth (PTB) is leading contributor to infant death in the United States and globally,
yet the underlying mechanistic causes are not well understood. Histopathological studies of …