MicroRNAs in rheumatoid arthritis: From pathogenesis to clinical impact

G Evangelatos, GE Fragoulis, V Koulouri… - Autoimmunity reviews, 2019 - Elsevier
Over the last decade, many epigenetic mechanisms that contribute in the pathogenesis of
autoimmune disorders have been revealed. MicroRNAs (miRNAs) are small, non-coding …

Epigenetic changes in the pathogenesis of rheumatoid arthritis

MV Nemtsova, DV Zaletaev, IV Bure… - Frontiers in …, 2019 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects about 1% of the
world's population. The etiology of RA remains unknown. It is considered to occur in the …

miRNAs as therapeutic targets in inflammatory disease

Q Lu, R Wu, M Zhao, A Garcia-Gomez… - Trends in pharmacological …, 2019 - cell.com
In the past decade, we have witnessed considerable developments in understanding the
roles and functions of miRNAs. In parallel, the identification of alterations in miRNA …

The role of microRNAs in newborn brain development and hypoxic ischaemic encephalopathy

V Ponnusamy, PK Yip - Neuropharmacology, 2019 - Elsevier
Neonates can develop hypoxic-ischaemic encephalopathy (HIE) due to lack of blood supply
or oxygen, resulting in a major cause of death and disability among term newborns …

Implications of the noncoding RNAs in rheumatoid arthritis pathogenesis

MJ Mousavi, A Jamshidi, A Chopra… - Journal of cellular …, 2019 - Wiley Online Library
Epigenetics refers to a set of regulatory mechanisms that affect gene expression, while the
original sequence of the DNA remains unchanged. Because the advance of noncoding …

MicroRNA and exosome: key players in rheumatoid arthritis

Z Zakeri, A Salmaninejad, N Hosseini… - Journal of Cellular …, 2019 - Wiley Online Library
Rheumatoid arthritis (RA) is known as one of important autoimmune disorders which can
lead to joint pain and damage throughout body. Given that internal (ie, genetic and …

MicroRNA mediate visfatin and resistin induction of oxidative stress in human osteoarthritic synovial fibroblasts via NF-κB pathway

S Cheleschi, I Gallo, M Barbarino, S Giannotti… - International Journal of …, 2019 - mdpi.com
Synovial membrane inflammation actively participate to structural damage during
osteoarthritis (OA). Adipokines, miRNA, and oxidative stress contribute to synovitis and …

MicroRNA‑34a‑3p inhibits proliferation of rheumatoid arthritis fibroblast‑like synoviocytes

C Hou, D Wang, L Zhang - Molecular medicine reports, 2019 - spandidos-publications.com
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by synovial
inflammation. Fibroblast‑like synoviocytes (FLS) serve a vital role in the initiation and …

MicroRNAs in rheumatoid arthritis: what is the latest with regards to diagnostics?

RY Huang, JQ Wu, ZH Liu, SL Sun - Expert Review of Molecular …, 2019 - Taylor & Francis
Rheumatoid arthritis (RA) is a systemic, chronic and inflammatory disease with unknown
etiology [1]. Characteristic features of RA are chronic synovitis and a fluctuating clinical …

Evaluation of the effects of miRNAs in familial Mediterranean fever

HO Hortu, E Karaca, B Sozeri, N Gulez, B Makay… - Clinical …, 2019 - Springer
Familial Mediterranean fever (FMF) is an inherited autoinflammatory disorder that can result
in attacks with accompanying recurrent episodes of fever, serositis, and skin rash. MiRNAs …