Mitochondrial dysfunction and multiple sclerosis
IP Barcelos, RM Troxell, JS Graves - Biology, 2019 - mdpi.com
In recent years, several studies have examined the potential associations between
mitochondrial dysfunction and neurodegenerative diseases such as multiple sclerosis (MS) …
mitochondrial dysfunction and neurodegenerative diseases such as multiple sclerosis (MS) …
Causal roles of mitochondrial dynamics in longevity and healthy aging
Mitochondria are organized in the cell in the form of a dynamic, interconnected network.
Mitochondrial dynamics, regulated by mitochondrial fission, fusion, and trafficking, ensure …
Mitochondrial dynamics, regulated by mitochondrial fission, fusion, and trafficking, ensure …
Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent
The mitochondrial membrane potential (ΔΨm) is the main driver of oxidative
phosphorylation (OXPHOS). The inner mitochondrial membrane (IMM), consisting of cristae …
phosphorylation (OXPHOS). The inner mitochondrial membrane (IMM), consisting of cristae …
Axonal transport and mitochondrial function in neurons
A Mandal, CM Drerup - Frontiers in Cellular Neuroscience, 2019 - frontiersin.org
The complex and elaborate architecture of a neuron poses a great challenge to the cellular
machinery which localizes proteins and organelles, such as mitochondria, to necessary …
machinery which localizes proteins and organelles, such as mitochondria, to necessary …
Reconstitution of the human nigro-striatal pathway on-a-chip reveals OPA1-dependent mitochondrial defects and loss of dopaminergic synapses
Stem cell-derived neurons are generally obtained in mass cultures that lack both spatial
organization and any meaningful connectivity. We implement a microfluidic system for long …
organization and any meaningful connectivity. We implement a microfluidic system for long …
Disorders of mitochondrial dynamics in peripheral neuropathy: clues from hereditary neuropathy and diabetes
AE Rumora, MG Savelieff, SA Sakowski… - International Review of …, 2019 - Elsevier
Peripheral neuropathy is a common and debilitating complication of diabetes and
prediabetes. Recent clinical studies have identified an association between the …
prediabetes. Recent clinical studies have identified an association between the …
Clinical‐genetic features and peculiar muscle histopathology in infantile DNM1L‐related mitochondrial epileptic encephalopathy
D Verrigni, M Di Nottia, A Ardissone, E Baruffini… - Human …, 2019 - Wiley Online Library
Mitochondria are highly dynamic organelles, undergoing continuous fission and fusion. The
DNM1L (dynamin‐1 like) gene encodes for the DRP1 protein, an evolutionary conserved …
DNM1L (dynamin‐1 like) gene encodes for the DRP1 protein, an evolutionary conserved …
Soluble ST2 promotes oxidative stress and inflammation in cardiac fibroblasts: an in vitro and in vivo study in aortic stenosis
L Matilla, J Ibarrola, V Arrieta, A Garcia-Pena… - Clinical …, 2019 - portlandpress.com
Abstract Background: Soluble ST2 (interleukin 1 receptor-like 1)(sST2) is involved in
inflammatory diseases and increased in heart failure (HF). We herein investigated sST2 …
inflammatory diseases and increased in heart failure (HF). We herein investigated sST2 …
Abnormal brown adipose tissue mitochondrial structure and function in IL10 deficiency
Background Inflammation is the most relevant mechanism linking obesity with insulin-
resistance and metabolic disease. It impacts the structure and function of tissues and organs …
resistance and metabolic disease. It impacts the structure and function of tissues and organs …
Structural and evolutionary characteristics of dynamin-related GTPase OPA1
OPA1 is a dynamin-related GTPase that controls mitochondrial fusion, cristae remodeling,
energetics and mtDNA maintenance. However, the molecular architecture of OPA1 is poorly …
energetics and mtDNA maintenance. However, the molecular architecture of OPA1 is poorly …