[HTML][HTML] Deciphering drug resistance in Mycobacterium tuberculosis using whole-genome sequencing: progress, promise, and challenges
Tuberculosis (TB) is a global infectious threat that is intensified by an increasing incidence of
highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium …
highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium …
[HTML][HTML] Genome-wide analysis of Mycobacterium tuberculosis polymorphisms reveals lineage-specific associations with drug resistance
Background Continuing evolution of the Mycobacterium tuberculosis (Mtb) complex
genomes associated with resistance to anti-tuberculosis drugs is threatening tuberculosis …
genomes associated with resistance to anti-tuberculosis drugs is threatening tuberculosis …
Genetics and roadblocks of drug resistant tuberculosis
J Perdigao, I Portugal - Infection, Genetics and Evolution, 2019 - Elsevier
Considering the extensive evolutionary history of Mycobacterium tuberculosis, anti-
Tuberculosis (TB) drug therapy exerts a recent selective pressure. However, in a …
Tuberculosis (TB) drug therapy exerts a recent selective pressure. However, in a …
[HTML][HTML] Whole genome sequencing of drug resistant Mycobacterium tuberculosis isolates from a high burden tuberculosis region of North West Pakistan
Tuberculosis (TB), caused by Mycobacterium tuberculosis bacteria, is a leading infectious
cause of mortality worldwide, including in Pakistan. Drug resistant M. tuberculosis is an …
cause of mortality worldwide, including in Pakistan. Drug resistant M. tuberculosis is an …
Azaaurones as potent antimycobacterial agents active against MDR‐and XDR‐TB
A Campaniço, MP Carrasco, M Njoroge… - …, 2019 - Wiley Online Library
Herein we report the screening of a small library of aurones and their isosteric counterparts,
azaaurones and N‐acetylazaaurones, against Mycobacterium tuberculosis. Aurones were …
azaaurones and N‐acetylazaaurones, against Mycobacterium tuberculosis. Aurones were …
[HTML][HTML] Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in …
J Perdigão, C Silva, J Diniz, C Pereira… - Infection, genetics and …, 2019 - Elsevier
Tuberculosis (TB) remains a major health problem within the Community of Portuguese
Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across …
Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across …
Evaluation of a gene-by-gene approach for prospective whole-genome sequencing-based surveillance of multidrug resistant Mycobacterium tuberculosis
Whole-genome sequencing (WGS) offers unprecedented resolution for tracking
Mycobacterium tuberculosis transmission and antibiotic-resistance spread. Still, the …
Mycobacterium tuberculosis transmission and antibiotic-resistance spread. Still, the …
[HTML][HTML] A nationwide study of multidrug-resistant tuberculosis in Portugal 2014–2017 using epidemiological and molecular clustering analyses
Background Increasing multidrug-resistant tuberculosis (MDR-TB) incidence is a major
threat against TB eradication worldwide. We aim to conduct a detailed MDR-TB study in …
threat against TB eradication worldwide. We aim to conduct a detailed MDR-TB study in …
Multidrug-resistant tuberculosis in Lisbon: unfavourable treatment and associated factors, 2000–2014
SETTING: The incidence of tuberculosis (TB) has been decreasing in Portugal. Lisbon
concentrates the largest number of cases of multidrug-resistant (MDR) TB in the country …
concentrates the largest number of cases of multidrug-resistant (MDR) TB in the country …
Insights on the Mycobacterium tuberculosis population structure associated with migrants from Portuguese-speaking countries over a three-year period in Greater …
Tuberculosis among foreign-born patients is a key indicator of country-level epidemiological
profiles and, of an increasing concern in Europe given the more intensified migratory waves …
profiles and, of an increasing concern in Europe given the more intensified migratory waves …