Abstract l-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in
the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp …

Inflammation aims to restore tissue homeostasis after injury or infection. Age-related decline
of tissue homeostasis causes a physiological low-grade chronic inflammatory phenotype …

Abstract Changes in cellular metabolism are associated with the activation of diverse
immune subsets. These changes are fuelled by nutrients including glucose, amino acids …

Dendritic cells (DCs) control innate and adaptive immunity by patrolling tissues to gather
antigens and danger signals derived from microbes and tissue. Subsequently, DCs integrate …

During tumorigenesis, breast tumour cells undergo metabolic reprogramming, which
generally includes enhanced glycolysis, tricarboxylic acid cycle activity, glutaminolysis and …

Many metabolic alterations, including the Warburg effect, occur in cancer cells that influence
the tumor microenvironment, including switching to glycolysis from oxidative …

Tryptophan catabolism is an attractive target for reducing tumor progression and improving
antitumor immunity in multiple cancers. Tumor infiltration by CD8 T cells correlates with …

After decades of intense effort, therapeutics that leverage the immune system to fight cancer
have now been conclusively demonstrated to be effective. Immuno-oncology has arrived …

Abstract Type I Interferons (IFN-I) mediate numerous immune interactions during viral
infections, from the establishment of an antiviral state to invoking and regulating innate and …

Cancer progression is closely related to the tumor microenvironment in which the tumor
exists, including surrounding blood vessels, immune cells, fibroblasts, bone marrow‐derived …