Nucleic acid sensors, primarily TLR and RLR family members, as well as cGAS–STING
signalling, play a critical role in the preservation of cellular and organismal homeostasis …

Synovial tissue is a membranous non-immune organ lining joint cavities where it supports
local immune responses, and functions directly and indirectly in joint destruction due to …

Rheumatoid arthritis (RA) is an autoimmune disease in which a variety of circulating pro-
inflammatory cells and dysregulated molecules are involved in disease aetiology and …

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by
inflammatory cell infiltration, high levels of cytokines, and erosion of cartilage and bone in …

Osteoarthritis (OA) affects the integrity of the entire joint including the synovium. The most
abundant cells in the synovium are fibroblasts (SF). Excessive mechanical loading might …

Toll-like receptors (TLRs) recognize pathogen/damage-associated molecular patterns and
initiate inflammatory signaling cascades. Occasionally, overexpression of TLRs leads to the …

Selection of appropriate housekeeping genes is essential for the validity of data
normalization in reverse transcription quantitative PCR (RT-qPCR). Synovial fibroblasts (SF) …

Rheumatoid arthritis (RA) is a chronic autoimmune disease of synovial inflammation and
joint destruction. This study reports anti-arthritic potential of opuntioside-I opuntiol, and its …

Fibroblast-like synoviocytes (FLSs) play a crucial role in rheumatoid arthritis (RA)
pathogenesis. While miRNA (miR)-506 has been implicated in the progression of multiple …

The era of next-generation sequencing has mounted the foundation of many gene
expression studies. In rheumatoid arthritis research, this has led to the discovery of important …