Most genome-wide association and fine-mapping studies to date have been conducted in
individuals of European descent, and genetic studies of populations of Hispanic/Latino and …

Hemoglobin (Hb) concentration is the outcome of the interaction between genetic variation
and environmental factors, including nutritional status, sex, age, and altitude. Genetic …

Loci discovered by genome-wide association studies predominantly map outside protein-
coding genes. The interpretation of the functional consequences of non-coding variants can …

The human genetic factors that affect resistance to infectious disease are poorly understood.
Here we report a genome-wide association study in 17,000 severe malaria cases and …

Excessive alcohol consumption is one of the main causes of death and disability worldwide.
Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of …

Purpose To establish a cohort that enables identification of genomic factors that influence
human health and empower increased blood donor health and safe blood transfusions …

Varicose veins of lower extremities (VVs) are a common multifactorial vascular disease.
Genetic factors underlying VVs development remain largely unknown. Here we report the …

In the last few years, the advent of new technological approaches has led to a better
knowledge of the ontogeny of erythropoiesis during development and of the journey leading …

Horizontal pleiotropy, where one variant has independent effects on multiple traits, is
important for our understanding of the genetic architecture of human phenotypes. We …

A major challenge for stem cell engineering is achieving a holistic understanding of the
molecular networks and biological processes governing cell differentiation. To address this …