Objective The goal of this narrative review is to provide an overview of migraine
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …

Introduction The trigeminal ganglion is unique among the somatosensory ganglia regarding
its topography, structure, composition and possibly some functional properties of its cellular …

Background Calcitonin gene-related peptide plays an important role in migraine
pathophysiology. We evaluated eptinezumab, an intravenous (IV) anti-calcitonin gene …

Premise Migraine is a complex neurologic disorder that leads to significant disability, yet
remains poorly understood. Problem One potential triggering mechanism in migraine with …

Objective To review clinical and pre-clinical evidence supporting the role of visual pathways,
from the eye to the cortex, in the development of photophobia in headache disorders …

Background Neuropathic pain is a serious clinical problem that needs to be solved urgently.
ASK1 is an upstream protein of p38 and JNK which plays important roles in …

Background Calcitonin gene-related peptide (CGRP) released from trigeminal nerve fibres
indicates trigeminal activation and has a key role in migraine pathophysiology. The …

Cortical spreading depression (CSD) is a wave of neuronal depolarization thought to
underlie migraine aura. Calcitonin gene-related peptide (CGRP) is a potent vasodilator …

Introduction Rodent disease models can play an indispensable role in drug development.
Confirming that translationally-relevant disease mechanisms are engaged in such models is …

Abstract Purpose of Review The purpose of the following review is to summarize the most
recent understanding of migraine pathophysiology, as well as of basic and clinical science …