Emerging and established modes of cell death during acetaminophen-induced liver injury
Acetaminophen (APAP)-induced liver injury is an important clinical and toxicological
problem. Understanding the mechanisms and modes of cell death are vital for the …
problem. Understanding the mechanisms and modes of cell death are vital for the …
Acetaminophen hepatotoxicity: A mitochondrial perspective
A Ramachandran, H Jaeschke - Advances in pharmacology, 2019 - Elsevier
Acetaminophen (APAP) is a highly effective analgesic, which is safe at therapeutic doses.
However, an overdose can cause hepatotoxicity and even liver failure. APAP toxicity is …
However, an overdose can cause hepatotoxicity and even liver failure. APAP toxicity is …
Protective effect of 7, 3′, 4′-flavon-3-ol (fisetin) on acetaminophen-induced hepatotoxicity in vitro and in vivo
L Zhao, J Zhang, L Pan, L Chen, Y Wang, X Liu, L You… - Phytomedicine, 2019 - Elsevier
Background Acetaminophen (APAP) overdose is a leading cause of drug-induced acute
liver failure in clinic. Fisetin (FST) is a phenolic compound that has been isolated from many …
liver failure in clinic. Fisetin (FST) is a phenolic compound that has been isolated from many …
The protective efficacy of soursop fruit extract against hepatic injury associated with acetaminophen exposure is mediated through antioxidant, anti-inflammatory, and …
AY Al-Brakati, MS Fouda, AM Tharwat… - … Science and Pollution …, 2019 - Springer
In the current report, we examined the potential beneficial role of soursop fruit extract (SSFE)
on liver injury induced by a single paracetamol (APAP) overdose (2000 mg/kg). Thirty-five …
on liver injury induced by a single paracetamol (APAP) overdose (2000 mg/kg). Thirty-five …
[HTML][HTML] Comparison of toxic responses to acetaminophen challenge in ICR mice originating from different sources
TB Jeong, JH Kim, SH Kim, S Lee, SW Son… - Laboratory animal …, 2019 - Springer
Acetaminophen (APAP) is the most common antipyretic analgesic worldwide. However,
APAP overdose causes severe liver injury, especially centrilobular necrosis, in humans and …
APAP overdose causes severe liver injury, especially centrilobular necrosis, in humans and …
5, 7, 3′, 4′-flavan-on-ol (taxifolin) protects against acetaminophen-induced liver injury by regulating the glutathione pathway
C Hu, J Ye, L Zhao, X Li, Y Wang, X Liu, L Pan, L You… - Life sciences, 2019 - Elsevier
Taxifolin (TAX) reportedly exerts protective and therapeutic effects in liver. Herein, the effects
of TAX against acetaminophen (APAP)-induced hepatotoxicity were investigated …
of TAX against acetaminophen (APAP)-induced hepatotoxicity were investigated …
Sediment quality assessment in the Guadalquivir River (SW, Spain) using caged Asian clams: A biomarker field approach
This study assesses the sediment quality of the Guadalquivir River watercourse between the
Alcalá del Río dam and the city of Seville. The main objective of this work is to address …
Alcalá del Río dam and the city of Seville. The main objective of this work is to address …
Biochemical strategies to counter nitrosative stress: nanofactories for value-added products
A Alhasawi, F Legendre, S Jagadeesan… - Microbial diversity in the …, 2019 - Elsevier
Reactive nitrogen species (RNS) such nitric oxide (NO) and its derivatives are a common
occurrence both in biotic and abiotic environments. In living systems, their formation is …
occurrence both in biotic and abiotic environments. In living systems, their formation is …
[HTML][HTML] Auriculatone sulfate effectively protects mice against acetaminophen-induced liver injury
L Lin, H Guan, R Li, X Liao, F Zhao, M Wang, J Li, G Xu… - Molecules, 2019 - mdpi.com
Acetaminophen (APAP) overdose is very common worldwide and has been widely
recognized as the leading cause of drug-induced liver injury in the Western world. In our …
recognized as the leading cause of drug-induced liver injury in the Western world. In our …
Microsomal prostaglandin E synthase 2 deficiency is resistant to acetaminophen-induced liver injury
H Wang, R Zhang, Y Zhu, T Teng, Y Cheng… - Archives of …, 2019 - Springer
Acetaminophen (APAP)-induced liver injury is the main cause of acute liver failure. This
study investigated the role of microsomal prostaglandin E synthase 2 (mPGES-2) …
study investigated the role of microsomal prostaglandin E synthase 2 (mPGES-2) …