Animal models of hypertension: a scientific statement from the American Heart Association
LO Lerman, TW Kurtz, RM Touyz, DH Ellison… - …, 2019 - Am Heart Assoc
Hypertension is the most common chronic disease in the world, yet the precise cause of
elevated blood pressure often cannot be determined. Animal models have been useful for …
elevated blood pressure often cannot be determined. Animal models have been useful for …
A decade in psychiatric GWAS research
After more than 10 years of accumulated efforts, genome-wide association studies (GWAS)
have led to many findings, most of which have been deposited into the GWAS Catalog …
have led to many findings, most of which have been deposited into the GWAS Catalog …
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure
to identify genes, tissues, phenomes and medication contexts of blood pressure …
to identify genes, tissues, phenomes and medication contexts of blood pressure …
Generalizing polygenic risk scores from Europeans to Hispanics/Latinos
Polygenic risk scores (PRSs) are weighted sums of risk allele counts of single‐nucleotide
polymorphisms (SNPs) associated with a disease or trait. PRSs are typically constructed …
polymorphisms (SNPs) associated with a disease or trait. PRSs are typically constructed …
Genome-wide association studies of hypertension and several other cardiovascular diseases
Y Wang, JG Wang - Pulse, 2019 - karger.com
Genome-wide association studies (GWAS) have greatly expanded our understanding of the
genetic architecture of cardiovascular diseases in the past decade. They have revealed …
genetic architecture of cardiovascular diseases in the past decade. They have revealed …
Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated
High blood pressure (BP) remains the major heritable and modifiable risk factor for
cardiovascular disease. Persistent high BP, or hypertension, is a complex trait with both …
cardiovascular disease. Persistent high BP, or hypertension, is a complex trait with both …
Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders
Human genetic adaptation to high altitudes (> 2500 m) has been extensively studied over
the last few years, but few functional adaptive genetic variants have been identified, largely …
the last few years, but few functional adaptive genetic variants have been identified, largely …
Cardiometabolic polygenic risk scores and osteoarthritis outcomes: a Mendelian randomization study using data from the Malmö Diet and Cancer Study and the UK …
G Hindy, KE Åkesson, O Melander… - Arthritis & …, 2019 - Wiley Online Library
Objective To investigate the causal role of cardiometabolic risk factors in osteoarthritis (OA)
using associated genetic variants. Methods We studied 27,691 adults from the Malmö Diet …
using associated genetic variants. Methods We studied 27,691 adults from the Malmö Diet …
Genetic basis of motoric cognitive risk syndrome in the Health and Retirement Study
Objective To examine polygenic inheritance of motoric cognitive risk syndrome (MCR), a
predementia syndrome characterized by the presence of subjective cognitive complaints …
predementia syndrome characterized by the presence of subjective cognitive complaints …
A genome‐wide association and replication study of blood pressure in Ugandan early adolescents
SA Lule, AJ Mentzer, B Namara… - Molecular genetics & …, 2019 - Wiley Online Library
Background Genetic association studies of blood pressure (BP) have mostly been
conducted in non‐African populations. Using the Entebbe Mother and Baby Study (EMaBS) …
conducted in non‐African populations. Using the Entebbe Mother and Baby Study (EMaBS) …