Coordinated dialogue between UHRF1 and DNMT1 to ensure faithful inheritance of methylated DNA patterns
DNA methylation, catalyzed by DNA methyltransferases (DNMTs), is an epigenetic mark that
needs to be faithfully replicated during mitosis in order to maintain cell phenotype during …
needs to be faithfully replicated during mitosis in order to maintain cell phenotype during …
Dysregulation of epigenetic mechanisms of gene expression in the pathologies of hyperhomocysteinemia
J Perła-Kaján, H Jakubowski - International journal of molecular sciences, 2019 - mdpi.com
Hyperhomocysteinemia (HHcy) exerts a wide range of biological effects and is associated
with a number of diseases, including cardiovascular disease, dementia, neural tube defects …
with a number of diseases, including cardiovascular disease, dementia, neural tube defects …
Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns
M Emperle, S Adam, S Kunert, M Dukatz… - Nucleic acids …, 2019 - academic.oup.com
Somatic DNMT3A mutations at R882 are frequently observed in AML patients including the
very abundant R882H, but also R882C, R882P and R882S. Using deep enzymology, we …
very abundant R882H, but also R882C, R882P and R882S. Using deep enzymology, we …
DNA methyltransferases: emerging targets for the discovery of inhibitors as potent anticancer drugs
J Yu, T Xie, Z Wang, X Wang, S Zeng, Y Kang… - Drug Discovery …, 2019 - Elsevier
Highlights•The structure-related regulatory mechanisms of active DNMTs are outlined.•The
therapeutic importance of DNMTs in different cancer types is briefly compared.•The most …
therapeutic importance of DNMTs in different cancer types is briefly compared.•The most …
DNA methylation processes in atherosclerotic plaque
E Aavik, M Babu, S Ylä-Herttuala - Atherosclerosis, 2019 - Elsevier
Underlying mechanisms of cardiovascular diseases (CVD) have been investigated for over
100 years and novel molecular level mechanisms in the pathophysiology are still …
100 years and novel molecular level mechanisms in the pathophysiology are still …
H3K36me2/3 binding and DNA binding of the DNA methyltransferase DNMT3A PWWP domain both contribute to its chromatin interaction
M Dukatz, K Holzer, M Choudalakis, M Emperle… - Journal of molecular …, 2019 - Elsevier
The PWWP domain of DNMT3 DNA methyltransferases binds to histone H3 tails containing
methylated K36, and this activity is important for heterochromatic targeting. Here, we show …
methylated K36, and this activity is important for heterochromatic targeting. Here, we show …
Methylation and transcription patterns are distinct in IDH mutant gliomas compared to other IDH mutant cancers
Mutations in isocitrate dehydrogenases 1 and 2 (IDHmut) are present in a variety of cancers,
including glioma, acute myeloid leukemia (AML), melanoma, and cholangiocarcinoma …
including glioma, acute myeloid leukemia (AML), melanoma, and cholangiocarcinoma …
DNA methylation status in cancer disease: modulations by plant-derived natural compounds and dietary interventions
The modulation of the activity of DNA methyltransferases (DNMTs) represents a crucial
epigenetic mechanism affecting gene expressions or DNA repair mechanisms in the cells …
epigenetic mechanism affecting gene expressions or DNA repair mechanisms in the cells …
CXXC5: A novel regulator and coordinator of TGF‐β, BMP and Wnt signaling
X Xiong, S Tu, J Wang, S Luo… - Journal of cellular and …, 2019 - Wiley Online Library
CXXC5 is a member of the CXXC‐type zinc‐finger protein family. Proteins in this family play
a pivotal role in epigenetic regulation by binding to unmethylated CpG islands in gene …
a pivotal role in epigenetic regulation by binding to unmethylated CpG islands in gene …
The “-OMICS” facet of melanoma: Heterogeneity of genomic, proteomic and metabolomic biomarkers
In the recent decade, cutting edge molecular and proteomic analysis platforms
revolutionized biomarkers discovery in cancers. Melanoma is the prototype with over 51,100 …
revolutionized biomarkers discovery in cancers. Melanoma is the prototype with over 51,100 …