Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous
cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; …

Toll-like receptors (TLRs) comprise a clan of proteins involved in identification and triggering
a suitable response against pathogenic attacks. As lung is steadily exposed to multiple …

Objective Chronic obstructive pulmonary disease (COPD) and pulmonary tuberculosis (PTB)
share a number of common risk factors, including innate immunity-related genetic factors. In …

Significance: G protein-coupled receptors (GPCR) are the largest group of cell surface
receptors, which link cells to their environment. Reactive oxygen species (ROS) can act as …

Aims: Oxidant-induced endothelial injury plays a critical role in the pathogenesis of acute
lung injury (ALI) and subsequent respiratory failure. Our previous studies revealed an …

We previously reported that the canonical innate immune receptor toll‐like receptor 4 (TLR4)
is critical in maintaining lung integrity. However, the molecular mechanisms via which TLR4 …

During the development of heart failure in humans and animal models, an increase in
reactive oxygen species (ROS) levels was observed. However, there is no information …

The human respiratory tract is exposed to environmental irritants on a daily basis. The innate
immune system is composed of different cellular components including the resident airway …

A presente dissertação de mestrado versa sobre os novos desenvolvimentos
neurocientíficos sobre a liberdade. A partir dos estudos de BENJAMIN LIBET foi …