Brain age prediction using deep learning uncovers associated sequence variants

BA Jónsson, G Bjornsdottir, TE Thorgeirsson… - Nature …, 2019 - nature.com
Abstract Machine learning algorithms can be trained to estimate age from brain structural
MRI. The difference between an individual's predicted and chronological age, predicted age …

IGFBP-2 signaling in the brain: from brain development to higher order brain functions

S Khan - Frontiers in Endocrinology, 2019 - frontiersin.org
Insulin-like growth factor-binding protein-2 (IGFBP-2) is a pleiotropic polypeptide that
functions as autocrine and/or paracrine growth factors. IGFBP-2 is the most abundant of the …

Population-based neuroimaging reveals traces of childbirth in the maternal brain

AMG de Lange, T Kaufmann… - Proceedings of the …, 2019 - National Acad Sciences
Maternal brain adaptations have been found across pregnancy and postpartum, but little is
known about the long-term effects of parity on the maternal brain. Using neuroimaging and …

Cumulative estrogen exposure, APOE genotype, and women's brain aging-a population-based neuroimaging study

AM de Lange, C Barth, T Kaufmann, II Maximov… - bioRxiv, 2019 - biorxiv.org
Estrogen exposure may influence women's risk of Alzheimer's disease, but little is known
about how it affects normal brain aging. Recent findings from the UK Biobank demonstrate …

Combining electrophysiology with MRI enhances learning of surrogate-biomarkers

DA Engemann, O Kozynets, D Sabbagh, G Lemaitre… - bioRxiv, 2019 - biorxiv.org
Electrophysiological methods, ie, M/EEG provide unique views into brain health. Yet, when
building predictive models from brain data, it is often unclear how electrophysiology should …

Differences in directed functional brain connectivity related to age and sex

MJ Lund, D Alnæs, S Schwab, D van der Meer… - bioRxiv, 2019 - biorxiv.org
Objective Functional interconnections between brain regions define the 'connectome'which
is of central interest for understanding human brain function, and is increasingly recognized …