Eculizumab and beyond: the past, present, and future of complement therapeutics

CJ Patriquin, KHM Kuo - Transfusion medicine reviews, 2019 - Elsevier
Dysregulation of the complement system underlies the pathophysiology of many diseases.
Renewed interest in complement occurred with the recognition that its therapeutic inhibition …

The role of complement in post-transfusion hemolysis and hyperhemolysis reaction

LT Roumenina, P Bartolucci, F Pirenne - Transfusion medicine reviews, 2019 - Elsevier
Transfusion-related hemolysis is classically the result of an interaction between antibodies
produced by the recipient and blood group antigens carried by the donor red blood cells …

[HTML][HTML] Factor H: a novel modulator in sickle cell disease

W El Nemer, B Koehl - haematologica, 2019 - ncbi.nlm.nih.gov
Sickle cell disease (SCD) is an autosomal recessive disor-der caused by a point mutation in
the β globin gene that substitutes glutamic acid (GAG) at position 6 of the protein into valine …