Cancer nanomedicine for combination cancer immunotherapy

J Nam, S Son, KS Park, W Zou, LD Shea… - Nature Reviews …, 2019 - nature.com
Cancer immunotherapy is revolutionizing oncology. However, dose-limiting toxicities and
low patient response rates remain major challenges in the clinic. Cancer nanomedicine in …

Three decades of messenger RNA vaccine development

R Verbeke, I Lentacker, SC De Smedt, H Dewitte - Nano Today, 2019 - Elsevier
In the early nineties, pioneering steps were taken in the use of mRNA as a therapeutic tool
for vaccination. In the following decades, an improved understanding of the mRNA …

Trial watch: dendritic cell vaccination for cancer immunotherapy

J Sprooten, J Ceusters, A Coosemans… - …, 2019 - Taylor & Francis
Dendritic-cells (DCs) have received considerable attention as potential targets for the
development of anticancer vaccines. DC-based anticancer vaccination relies on patient …

Emerging nano‐/microapproaches for cancer immunotherapy

Y Mi, CT Hagan IV, BG Vincent, AZ Wang - Advanced Science, 2019 - Wiley Online Library
Cancer immunotherapy has achieved remarkable clinical efficacy through recent advances
such as chimeric antigen receptor‐T cell (CAR‐T) therapy, immune checkpoint blockade …

Co-delivery of cisplatin and doxorubicin by covalently conjugating with polyamidoamine dendrimer for enhanced synergistic cancer therapy

XL Guo, XX Kang, YQ Wang, XJ Zhang, CJ Li, Y Liu… - Acta biomaterialia, 2019 - Elsevier
Because of the synergistic effects of drugs and minimal drug dose for cancer therapy,
combination chemotherapy is frequently used in the clinic. In this study, hyaluronic acid …

Nanoparticle‐based nanomedicines to promote cancer immunotherapy: recent advances and future directions

J Liu, R Zhang, ZP Xu - Small, 2019 - Wiley Online Library
Cancer immunotherapy is a promising cancer terminator by directing the patient's own
immune system in the fight against this challenging disorder. Despite the monumental …

A concise review on cancer treatment methods and delivery systems

E Bidram, Y Esmaeili, H Ranji-Burachaloo… - Journal of Drug Delivery …, 2019 - Elsevier
The ultimate purpose of current cancer research is to develop a comprehensive treatment for
cancer. Recent studies have shown an increased interest in investigating the capacity of …

Broadening the message: a nanovaccine co-loaded with messenger RNA and α-GalCer induces antitumor immunity through conventional and natural killer T cells

R Verbeke, I Lentacker, K Breckpot, J Janssens… - ACS …, 2019 - ACS Publications
Messenger RNA encoding tumor antigens has the potential to evoke effective antitumor
immunity. This study reports on a nanoparticle platform, named mRNA Galsomes, that …

The application of nanotechnology in enhancing immunotherapy for cancer treatment: current effects and perspective

Y Li, C Ayala-Orozco, PR Rauta, S Krishnan - Nanoscale, 2019 - pubs.rsc.org
Cancer immunotherapy is emerging as a promising treatment modality that suppresses and
eliminates tumors by re-activating and maintaining the tumor-immune cycle, and further …

[HTML][HTML] Nanosoldiers: A promising strategy to combat triple negative breast cancer

A Pawar, P Prabhu - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Abstracts The phenomenal rise in cancer over the past few years has made it the second
leading cause of death worldwide. Breast cancer constitutes the predominant cancer …