Quality control in Huntington's disease: A therapeutic target
Huntington's disease (HD) is a fatal autosomal dominantly inherited brain disease caused
by excessively expanded CAG repeats in gene which encodes huntingtin protein. These …
by excessively expanded CAG repeats in gene which encodes huntingtin protein. These …
Laquinimod treatment improves myelination deficits at the transcriptional and ultrastructural levels in the YAC128 mouse model of Huntington disease
M Garcia-Miralles, NABM Yusof, JY Tan… - Molecular …, 2019 - Springer
Laquinimod, an immunomodulatory agent under clinical development for Huntington
disease (HD), has recently been shown to confer behavioural improvements that are …
disease (HD), has recently been shown to confer behavioural improvements that are …
Astrocyte transduction is required for rescue of behavioral phenotypes in the YAC128 mouse model with AAV-RNAi mediated HTT lowering therapeutics
LM Stanek, J Bu, LS Shihabuddin - Neurobiology of Disease, 2019 - Elsevier
Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disease
caused by a CAG expansion, which translates into an elongated polyglutamine (polyQ) …
caused by a CAG expansion, which translates into an elongated polyglutamine (polyQ) …
Lysine methylation regulates nervous system diseases
Z Wang, H Liu - Neuropeptides, 2019 - Elsevier
Lysine methylation is an important dynamic modification which is essential in the epigenetic
regulation of gene transcription. Unlike acetylation markers, lysine methylation signals at …
regulation of gene transcription. Unlike acetylation markers, lysine methylation signals at …
[PDF][PDF] L'UNIVERSITE PARIS-SACLAY
A Najia - core.ac.uk
104 preclinical patients were unimpaired in both IGT and GDT tasks. They performed
similarly than healthy controls in all executive tasks. By contrast, clinical HD patients were …
similarly than healthy controls in all executive tasks. By contrast, clinical HD patients were …
THE CORTICOSTRIATAL COMMUNICATION PROBLEM IN HUNTINGTON'S DISEASE: DEFICITS IN ASCORBATE RELEASE AND GLUTAMATE UPTAKE
GV Rebec - Compendium Of In Vivo Monitoring In Real-time …, 2019 - books.google.com
Neurons are designed to communicate and communication between the cerebral cortex and
the striatum plays a key role in behavior—from movement selection and habit formation to …
the striatum plays a key role in behavior—from movement selection and habit formation to …
[HTML][HTML] Energy metabolism as a target for new treatment strategies in Huntington's disease
M Sjögren - 2019 - lup.lub.lu.se
Huntington´ s disease (HD) is a fatal inherited neurodegenerative disorder caused by a CAG
triplet repeat expansion in the huntingtin (HTT) gene and characterized by cognitive and …
triplet repeat expansion in the huntingtin (HTT) gene and characterized by cognitive and …