Is resolution the end of inflammation?

KT Feehan, DW Gilroy - Trends in molecular medicine, 2019 - cell.com
Deciphering the origins of chronic inflammatory and autoimmune diseases remains elusive
with reliance on therapies aimed at halting inflammation in its tracks. In recent years, an …

Mediators of the resolution of the inflammatory response

MA Sugimoto, JP Vago, M Perretti, MM Teixeira - Trends in immunology, 2019 - cell.com
The termination of inflammation is governed by endogenous molecules collectively referred
to as 'mediators of resolution'of inflammation. There is now strong evidence to suggest that …

Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes

JP Vago, MA Sugimoto, KM Lima… - Frontiers in …, 2019 - frontiersin.org
Inflammation resolution is an active process that functions to restore tissue homeostasis.
Clearance of apoptotic leukocytes by efferocytosis at inflammatory sites plays an important …

Angiotensin‐(1‐7) and Alamandine Promote Anti‐inflammatory Response in Macrophages In Vitro and In Vivo

M de Carvalho Santuchi, MF Dutra… - Mediators of …, 2019 - Wiley Online Library
The renin‐angiotensin system (RAS) peptides play an important role in inflammation.
Resolution of inflammation contributes to restore tissue homeostasis, and it is characterized …

Neuroinflammation in hypertension: the renin-angiotensin system versus pro-resolution pathways

FE Mowry, VC Biancardi - Pharmacological Research, 2019 - Elsevier
Overstimulation of the pro-inflammatory pathways within brain areas responsible for
sympathetic outflow is well evidenced as a primary contributing factor to the establishment …

ROCK inhibition drives resolution of acute inflammation by enhancing neutrophil apoptosis

I Galvão, RM Athayde, DA Perez, AC Reis, L Rezende… - Cells, 2019 - mdpi.com
Uncontrolled inflammation leads to tissue damage and it is central for the development of
chronic inflammatory diseases and autoimmunity. An acute inflammatory response is finely …

Targeting allosteric site of AKT by 5, 7-dimethoxy-1, 4-phenanthrenequinone suppresses neutrophilic inflammation

PJ Chen, IL Ko, CL Lee, HC Hu, FR Chang, YC Wu… - …, 2019 - thelancet.com
Background Acute lung injury (ALI) is a severe life-threatening inflammatory disease.
Neutrophil activation is a major pathogenic factor in ALI. Protein kinase B (PKB)/AKT …

Isoforskolin and forskolin attenuate lipopolysaccharide‐induced inflammation through TLR4/MyD88/NF‐κB cascades in human mononuclear leukocytes

X Du, R Shi, Y Wang, W Wu, S Sun, Z Dai… - Phytotherapy …, 2019 - Wiley Online Library
The principal active component of isoforskolin (ISOF) is from the plant Coleus forskohlii,
native to China, which has attracted much attention for its biological effects. We hypothesize …

Inhibition of the sphingosine‐1‐phosphate pathway promotes the resolution of neutrophilic inflammation

DA Perez, I Galvao, RM Athayde… - European Journal of …, 2019 - Wiley Online Library
Abstract Sphingosine‐1‐phosphate (S1P) is an important sphingolipid derived from plasma
membrane and has a known role in productive phase of inflammation, but its role in …

An evaluation of roflumilast and PDE4 inhibitors with a focus on the treatment of asthma

D Al-Sajee, X Yin, GM Gauvreau - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Asthma is a common chronic airway inflammatory disease characterized by
diverse inflammatory events leading to airway hyperresponsiveness and reversible airflow …