Is resolution the end of inflammation?
KT Feehan, DW Gilroy - Trends in molecular medicine, 2019 - cell.com
Deciphering the origins of chronic inflammatory and autoimmune diseases remains elusive
with reliance on therapies aimed at halting inflammation in its tracks. In recent years, an …
with reliance on therapies aimed at halting inflammation in its tracks. In recent years, an …
Mediators of the resolution of the inflammatory response
The termination of inflammation is governed by endogenous molecules collectively referred
to as 'mediators of resolution'of inflammation. There is now strong evidence to suggest that …
to as 'mediators of resolution'of inflammation. There is now strong evidence to suggest that …
Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes
JP Vago, MA Sugimoto, KM Lima… - Frontiers in …, 2019 - frontiersin.org
Inflammation resolution is an active process that functions to restore tissue homeostasis.
Clearance of apoptotic leukocytes by efferocytosis at inflammatory sites plays an important …
Clearance of apoptotic leukocytes by efferocytosis at inflammatory sites plays an important …
Angiotensin‐(1‐7) and Alamandine Promote Anti‐inflammatory Response in Macrophages In Vitro and In Vivo
M de Carvalho Santuchi, MF Dutra… - Mediators of …, 2019 - Wiley Online Library
The renin‐angiotensin system (RAS) peptides play an important role in inflammation.
Resolution of inflammation contributes to restore tissue homeostasis, and it is characterized …
Resolution of inflammation contributes to restore tissue homeostasis, and it is characterized …
Neuroinflammation in hypertension: the renin-angiotensin system versus pro-resolution pathways
FE Mowry, VC Biancardi - Pharmacological Research, 2019 - Elsevier
Overstimulation of the pro-inflammatory pathways within brain areas responsible for
sympathetic outflow is well evidenced as a primary contributing factor to the establishment …
sympathetic outflow is well evidenced as a primary contributing factor to the establishment …
ROCK inhibition drives resolution of acute inflammation by enhancing neutrophil apoptosis
I Galvão, RM Athayde, DA Perez, AC Reis, L Rezende… - Cells, 2019 - mdpi.com
Uncontrolled inflammation leads to tissue damage and it is central for the development of
chronic inflammatory diseases and autoimmunity. An acute inflammatory response is finely …
chronic inflammatory diseases and autoimmunity. An acute inflammatory response is finely …
Targeting allosteric site of AKT by 5, 7-dimethoxy-1, 4-phenanthrenequinone suppresses neutrophilic inflammation
Background Acute lung injury (ALI) is a severe life-threatening inflammatory disease.
Neutrophil activation is a major pathogenic factor in ALI. Protein kinase B (PKB)/AKT …
Neutrophil activation is a major pathogenic factor in ALI. Protein kinase B (PKB)/AKT …
Isoforskolin and forskolin attenuate lipopolysaccharide‐induced inflammation through TLR4/MyD88/NF‐κB cascades in human mononuclear leukocytes
X Du, R Shi, Y Wang, W Wu, S Sun, Z Dai… - Phytotherapy …, 2019 - Wiley Online Library
The principal active component of isoforskolin (ISOF) is from the plant Coleus forskohlii,
native to China, which has attracted much attention for its biological effects. We hypothesize …
native to China, which has attracted much attention for its biological effects. We hypothesize …
Inhibition of the sphingosine‐1‐phosphate pathway promotes the resolution of neutrophilic inflammation
DA Perez, I Galvao, RM Athayde… - European Journal of …, 2019 - Wiley Online Library
Abstract Sphingosine‐1‐phosphate (S1P) is an important sphingolipid derived from plasma
membrane and has a known role in productive phase of inflammation, but its role in …
membrane and has a known role in productive phase of inflammation, but its role in …
An evaluation of roflumilast and PDE4 inhibitors with a focus on the treatment of asthma
D Al-Sajee, X Yin, GM Gauvreau - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Asthma is a common chronic airway inflammatory disease characterized by
diverse inflammatory events leading to airway hyperresponsiveness and reversible airflow …
diverse inflammatory events leading to airway hyperresponsiveness and reversible airflow …