The interplay among psychological distress, the immune system, and brain tumor patient outcomes
Highlights•Depression and psychological distress are prevalent in patients with brain
tumors.•Chronic distress leads to increased adrenergic signaling and immunosuppression.• …
tumors.•Chronic distress leads to increased adrenergic signaling and immunosuppression.• …
Recent advances in the discovery of small molecules targeting glioblastoma
GF dos Santos Fernandes, BC Fernandes… - European Journal of …, 2019 - Elsevier
Glioblastoma (GBM) is one of the most common central nervous system cancers. It is
characterized as a fast-growing tumor that arises from multiple cell types with neural stem …
characterized as a fast-growing tumor that arises from multiple cell types with neural stem …
[HTML][HTML] Are the Statins promising antifungal agents against invasive candidiasis?
WG Lima, LA Alves-Nascimento, JT Andrade… - Biomedicine & …, 2019 - Elsevier
The medical importance of intra-abdominal candidiasis (IAC) contrasts with the limited
number of pharmacological treatment options available and the increasing rate of resistance …
number of pharmacological treatment options available and the increasing rate of resistance …
Enhanced copper–temozolomide interactions by protein for chemotherapy against glioblastoma multiforme
Current treatment of recurrent glioblastoma multiforme (GBM) demands dose-intense
temozolomide (TMZ), a prodrug of 5-(3-methyltriazen-1-yl) imidazole-4-carboxamide (MTIC) …
temozolomide (TMZ), a prodrug of 5-(3-methyltriazen-1-yl) imidazole-4-carboxamide (MTIC) …
Development of orthogonal linear separation analysis (OLSA) to decompose drug effects into basic components
T Mizuno, S Kinoshita, T Ito, S Maedera… - Scientific Reports, 2019 - nature.com
Drugs have multiple, not single, effects. Decomposition of drug effects into basic
components helps us to understand the pharmacological properties of a drug and …
components helps us to understand the pharmacological properties of a drug and …
Novel therapies hijack the blood–brain barrier to eradicate glioblastoma cancer stem cells
Glioblastoma (GBM) is amongst the most aggressive brain tumors with a dismal prognosis.
Despite significant advances in the current multimodality therapy including surgery …
Despite significant advances in the current multimodality therapy including surgery …
[HTML][HTML] Drug repositioning and biomarkers in low-grade glioma via bioinformatics approach
Aim Diffuse low-grade glioma (LGG) patients have a tendency to develop glioblastoma
multiforme within 5–10 years, with only 15 months life expectancy. The present study aimed …
multiforme within 5–10 years, with only 15 months life expectancy. The present study aimed …
The role of fibroblast growth factors and their receptors in gliomas: the mutations involved
V Georgiou, V Gkretsi - Reviews in the Neurosciences, 2019 - degruyter.com
The central nervous system (CNS) comprises of neurons, which are responsible for impulse
transmission, and glial cells, which surround neurons providing protection and nutrition …
transmission, and glial cells, which surround neurons providing protection and nutrition …
EphA3 is up-regulated by epidermal growth factor and promotes formation of glioblastoma cell aggregates
M Toyama, Y Hamaoka, H Katoh - Biochemical and biophysical research …, 2019 - Elsevier
EphA3, a member of the Eph family of receptor tyrosine kinases, has been reported to be
overexpressed in some human cancers including glioblastoma. Here, we found that …
overexpressed in some human cancers including glioblastoma. Here, we found that …
Human protein complex signatures for drug repositioning
Drug repositioning approaches are attracting more and more attentions in drug discovery
field. Benefiting from the high-throughput gene expression data, many computational drug …
field. Benefiting from the high-throughput gene expression data, many computational drug …