Just as oncogene activation and tumor suppressor loss are hallmarks of tumor development,
emerging evidence indicates that tumor microenvironment-mediated changes in …

Biomechanical changes in the heart and vessels drive rapid and dynamic regulation of
blood flow, a vital process for meeting the changing metabolic needs of the peripheral …

Leukocyte transendothelial migration is one of the most important step in launching an
inflammatory immune response and chronic inflammation can lead to devastating diseases …

Just as oncogene activation and tumor suppressor loss are hallmarks of tumor development,
emerging evidence indicates that tumor microenvironment-mediated changes in …

Background The main role of platelets is to control haemostasis when there is a blood
vessel injury in order to minimise blood loss at the injury site. Under normal circumstances …

In response to hemorrhage, circulating platelets roll on exposed subendothelium, adhere,
and form aggregates to seal a vascular leak. These processes involve platelet receptors …

Platelet activation is tightly regulated by inhibitory mechanisms that limit platelet
accumulation at sites of vascular injury. This chapter covers the most well-established …

Due to the lack of suitable in-vivo models, the etiology of intrahepatic cholangiocellular
carcinoma (ICC) is poorly understood. We previously showed the involvement of platelet …

Peanut agglutinin (PNA) is a dietary lectin which accounts for 0.15% of the total weight of
peanut Arachis hypogaea. PNA is a galactoside-binding protein which binds highly …

Objectives One of the more devastating chronic complications of diabetes mellitus (DM) is
diabetic nephropathy (DN), with a chronic low-grade inflammation occurring in the …