The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments
MC Morganti-Kossmann, BD Semple, SC Hellewell… - Acta …, 2019 - Springer
This review recounts the definitions and research evidence supporting the multifaceted roles
of neuroinflammation in the injured brain following trauma. We summarise the literature …
of neuroinflammation in the injured brain following trauma. We summarise the literature …
In search of antiepileptogenic treatments for post-traumatic epilepsy
Post-traumatic epilepsy (PTE) is diagnosed in 20% of individuals with acquired epilepsy,
and can impact significantly the quality of life due to the seizures and other functional or …
and can impact significantly the quality of life due to the seizures and other functional or …
MiR-124 enriched exosomes promoted the M2 polarization of microglia and enhanced hippocampus neurogenesis after traumatic brain injury by inhibiting TLR4 …
Y Yang, Y Ye, C Kong, X Su, X Zhang, W Bai… - Neurochemical …, 2019 - Springer
Abstract MicroRNA-124 (miR-124) is a brain specific miRNA that is highly expressed in
microglia. The upregulation of miR-124 contributes to M2 polarization of microglia, which is …
microglia. The upregulation of miR-124 contributes to M2 polarization of microglia, which is …
The astrocytic cAMP pathway in health and disease
Astrocytes are major glial cells that play critical roles in brain homeostasis. Abnormalities in
astrocytic functions can lead to brain disorders. Astrocytes also respond to injury and …
astrocytic functions can lead to brain disorders. Astrocytes also respond to injury and …
Anti-inflammatory Effects of Traditional Chinese Medicines on Preclinical in vivo Models of Brain Ischemia-Reperfusion-Injury: Prospects for Neuroprotective Drug …
Acquired brain ischemia-and reperfusion-injury (IRI), including both Ischemic stroke (IS) and
Traumatic Brain injury (TBI), is one of the most common causes of disability and death in …
Traumatic Brain injury (TBI), is one of the most common causes of disability and death in …
Aged rats have an altered immune response and worse outcomes after traumatic brain injury
M Sun, RD Brady, PM Casillas-Espinosa… - Brain, behavior, and …, 2019 - Elsevier
Initial studies suggest that increased age is associated with worse outcomes after traumatic
brain injury (TBI), though the pathophysiological mechanisms responsible for this remain …
brain injury (TBI), though the pathophysiological mechanisms responsible for this remain …
Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences
High mobility group box protein-1 (HMGB1) has been implicated as a key mediator of
neuroinflammation and neurodegeneration in a range of neurological conditions including …
neuroinflammation and neurodegeneration in a range of neurological conditions including …
Targeting neurodegeneration to prevent post-traumatic epilepsy
In the quest for developing new therapeutic targets for post-traumatic epilepsies (PTE),
identifying mechanisms relevant to development and progression of disease is critical. A …
identifying mechanisms relevant to development and progression of disease is critical. A …
Mild closed-head injury in conscious rats causes transient neurobehavioral and glial disturbances: a novel experimental model of concussion
Rodent models can provide insights into the most pertinent issues surrounding concussion.
Nonetheless, the relevance of some existing models to clinical concussion can be …
Nonetheless, the relevance of some existing models to clinical concussion can be …
Transactive response DNA-binding protein 43 abnormalities after traumatic brain injury
Initial studies have found some evidence for transactive response DNA-binding protein 43
(TDP-43) abnormalities after traumatic brain injury (TBI), and the presence of protein …
(TDP-43) abnormalities after traumatic brain injury (TBI), and the presence of protein …