Engineered materials for organoid systems
Organoids are 3D cell culture systems that mimic some of the structural and functional
characteristics of an organ. Organoid cultures provide the opportunity to study organ-level …
characteristics of an organ. Organoid cultures provide the opportunity to study organ-level …
The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells
CT Mierke - Reports on Progress in Physics, 2019 - iopscience.iop.org
The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
Hyperphysiological compression of articular cartilage induces an osteoarthritic phenotype in a cartilage-on-a-chip model
Owing to population aging, the social impact of osteoarthritis (OA)—the most common
musculoskeletal disease—is expected to increase dramatically. Yet, therapy is still limited to …
musculoskeletal disease—is expected to increase dramatically. Yet, therapy is still limited to …
3D bioprinting for high-throughput screening: Drug screening, disease modeling, and precision medicine applications
A Mazzocchi, S Soker, A Skardal - Applied Physics Reviews, 2019 - pubs.aip.org
High-throughput technologies have become essential in many fields of pharmaceutical and
biological development and production. Such technologies were initially developed with …
biological development and production. Such technologies were initially developed with …
Cell migration: implications for repair and regeneration in joint disease
Connective tissues within the synovial joints are characterized by their dense extracellular
matrix and sparse cellularity. With injury or disease, however, tissues commonly experience …
matrix and sparse cellularity. With injury or disease, however, tissues commonly experience …
Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration
Cells select from a diverse repertoire of migration strategies. Recent developments in
tunable biomaterials have helped identify how extracellular matrix properties influence …
tunable biomaterials have helped identify how extracellular matrix properties influence …
A versatile biosynthetic hydrogel platform for engineering of tissue analogues
For creating functional tissue analogues in tissue engineering, stem cells require very
specific 3D microenvironments to thrive and mature. Demanding (stem) cell types that are …
specific 3D microenvironments to thrive and mature. Demanding (stem) cell types that are …
Synthetic 3D PEG-anisogel tailored with fibronectin fragments induce aligned nerve extension
C Licht, JC Rose, AO Anarkoli, D Blondel… - …, 2019 - ACS Publications
An enzymatically cross-linked polyethylene glycol (PEG)-based hydrogel was engineered to
promote and align nerve cells in a three-dimensional manner. To render the injectable …
promote and align nerve cells in a three-dimensional manner. To render the injectable …
Rationally Designed 3D Hydrogels Model Invasive Lung Diseases Enabling High‐Content Drug Screening
Cell behavior is highly dependent upon microenvironment. Thus, to identify drugs targeting
metastatic cancer, screens need to be performed in tissue mimetic substrates that allow cell …
metastatic cancer, screens need to be performed in tissue mimetic substrates that allow cell …
Cell encapsulation in soft, anisometric poly (ethylene) glycol microgels using a novel radical‐free microfluidic system
LPB Guerzoni, JC Rose, DB Gehlen, A Jans, T Haraszti… - Small, 2019 - Wiley Online Library
Complex 3D artificial tissue constructs are extensively investigated for tissue regeneration.
Frequently, materials and cells are delivered separately without benefitting from the …
Frequently, materials and cells are delivered separately without benefitting from the …