Drug delivery into the brain is regulated by the blood–brain interfaces. The blood–brain
barrier (BBB), the blood–cerebrospinal fluid barrier (BCSFB), and the blood–arachnoid …

The concentration and distribution of a drug or its metabolites in tissues are key factors for
understanding drug efficacy or toxicity. Conventional pharmacokinetic studies show that the …

Imaging mass spectrometry (IMS) enables the spatially targeted molecular assessment of
biological tissues at cellular resolutions. New developments and technologies are essential …

Visualizing the distributions of drugs and their metabolites is one of the key emerging
application areas of matrix-assisted laser desorption/ionization–mass spectrometry imaging …

In many aspects of the matrix-assisted laser desorption/ionization mass spectrometry
imaging (MALDI MSI) technique, the discovery of new MALDI matrixes has been a major …

Recent advances in the understanding of basic pathological mechanisms in various
neurological diseases depend directly on the development of novel bioanalytical …

It is highly challenging to quantitatively map multiple analytes in biotissues without specific
chemical labeling. Quantitative mass spectrometry imaging (QMSI) has this potential but still …

Within drug development and pre-clinical trials, a common, significant and poorly
understood event is the development of drug-induced lipidosis in tissues and cells. In this …

Monoamine neurotransmitters are released by specialized neurons regulating behavioral,
motor, and cognitive functions. Although the localization of monoaminergic neurons in the …

The neurotransmitter of the cholinergic system, acetylcholine plays a major role in the brain's
cognitive function and is involved in neurodegenerative disorders. Here, we present age …