Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues
Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed
from a research tool to a clinical application for the diagnosis and management of …
from a research tool to a clinical application for the diagnosis and management of …
Deciphering Within-Host Microevolution of Mycobacterium tuberculosis through Whole-Genome Sequencing: the Phenotypic Impact and Way Forward
SD Ley, M de Vos, A Van Rie… - … and Molecular Biology …, 2019 - Am Soc Microbiol
The Mycobacterium tuberculosis genome is more heterogenous and less genetically stable
within the host than previously thought. Currently, only limited data exist on the within-host …
within the host than previously thought. Currently, only limited data exist on the within-host …
GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions
Drug resistance diagnostics that rely on the detection of resistance-related mutations could
expedite patient care and TB eradication. We perform minimum inhibitory concentration …
expedite patient care and TB eradication. We perform minimum inhibitory concentration …
Macro-geographical specificities of the prevailing tuberculosis epidemic as seen through SITVIT2, an updated version of the Mycobacterium tuberculosis genotyping …
In order to provide a global overview of genotypic, epidemiologic, demographic,
phylogeographical, and drug resistance characteristics related to the prevailing tuberculosis …
phylogeographical, and drug resistance characteristics related to the prevailing tuberculosis …
The molecular clock of Mycobacterium tuberculosis
The molecular clock and its phylogenetic applications to genomic data have changed how
we study and understand one of the major human pathogens, Mycobacterium tuberculosis …
we study and understand one of the major human pathogens, Mycobacterium tuberculosis …
Evaluation of whole-genome sequence method to diagnose resistance of 13 anti-tuberculosis drugs and characterize resistance genes in clinical multi-drug …
X Chen, G He, S Wang, S Lin, J Chen… - Frontiers in …, 2019 - frontiersin.org
Background: Whole-genome sequencing (WGS) is a viable and financially feasible tool for
timely and comprehensive diagnosis of drug resistance in developed countries. With the …
timely and comprehensive diagnosis of drug resistance in developed countries. With the …
Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture
Background Repeated culture reduces within-sample Mycobacterium tuberculosis genetic
diversity due to selection of clones suited to growth in culture and/or random loss of …
diversity due to selection of clones suited to growth in culture and/or random loss of …
Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex
Models on how bacterial lineages differentiate increase our understanding of early bacterial
speciation events and the genetic loci involved. Here, we analyze the population genomics …
speciation events and the genetic loci involved. Here, we analyze the population genomics …
[HTML][HTML] Towards standardisation: comparison of five whole genome sequencing (WGS) analysis pipelines for detection of epidemiologically linked tuberculosis cases
Background Whole genome sequencing (WGS) is a reliable tool for studying tuberculosis
(TB) transmission. WGS data are usually processed by custom-built analysis pipelines with …
(TB) transmission. WGS data are usually processed by custom-built analysis pipelines with …
Reference set of Mycobacterium tuberculosis clinical strains: A tool for research and product development
The Mycobacterium tuberculosis complex (MTBC) causes tuberculosis (TB) in humans and
various other mammals. The human-adapted members of the MTBC comprise seven …
various other mammals. The human-adapted members of the MTBC comprise seven …