Background Cancers with a defective DNA mismatch repair (dMMR) system contain
thousands of mutations most frequently located in monomorphic microsatellites and are …

Lynch syndrome is a hereditary cancer predisposition syndrome caused by germline
alterations in the mismatch repair genes and is the most common etiology of hereditary …

The prevalence of Lynch syndrome (LS) varies significantly in different populations,
suggesting that ethnic features might play an important role. We enrolled 3330 consecutive …

Objective This study aims to screen the MSI detection loci suitable for the East Asian
colorectal cancer patients. and explore its intratumoral heterogeneity. Methods A total of 271 …

Background Lynch syndrome is a hereditary cancer syndrome caused by constitutional
pathogenic variants in the DNA mismatch repair (MMR) system, leading to increased risk of …

Background Clinical benefit from checkpoint inhibitors has been associated in a tumor-
agnostic manner with two main tumor traits. The first is tumor antigenicity, which is typically …

Purpose of review Identification of Lynch syndrome is important from an individual patient
and public health standpoint. As paradigms for Lynch syndrome diagnosis have shifted in …

Most patients with Cowden syndrome have lesions in the gastrointestinal tract, characterized
by multiple polyps of various histologic types in the large bowel, polyps in the upper …

Background Lynch syndrome (LS) is the commonest inherited cancer syndrome caused by
pathogenic variants of germline DNA mismatch repair (g. MMR) genes. Genome‐wide …

Aim Colorectal cancer (CRC) is diagnosed in approximately 45 000 people annually in the
UK, and it is estimated that Lynch syndrome (LS) accounts for 3.1% of these cases. In …