Warburg effect in Gynecologic cancers
Y Kobayashi, K Banno, H Kunitomi… - Journal of Obstetrics …, 2019 - Wiley Online Library
Mammalian cells produce energy by oxidative phosphorylation under aerobic conditions.
However, in the 1920s, Otto Warburg reported the so‐called “Warburg effect” in which …
However, in the 1920s, Otto Warburg reported the so‐called “Warburg effect” in which …
Current prospects of molecular therapeutics in head and neck squamous cell carcinoma
K Devaraja - Pharmaceutical medicine, 2019 - Springer
Head and neck squamous cell carcinoma (HNSCC) has an estimated annual global death
rate of approximately 300,000. Despite advances in surgical techniques, the advent of …
rate of approximately 300,000. Despite advances in surgical techniques, the advent of …
Cigarette smoke induces metabolic reprogramming of the tumor stroma in head and neck squamous cell carcinoma
M Domingo-Vidal, D Whitaker-Menezes… - Molecular Cancer …, 2019 - AACR
Head and neck squamous cell carcinoma (HNSCC) is comprised of metabolically linked
distinct compartments. Cancer-associated fibroblasts (CAF) and nonproliferative carcinoma …
distinct compartments. Cancer-associated fibroblasts (CAF) and nonproliferative carcinoma …
[HTML][HTML] Targeting cellular metabolism to reduce head and neck cancer growth
Head and neck squamous cell carcinoma (HNSCC) presents a major public health concern
because of delayed diagnosis and poor prognosis. Malignant cells often reprogram their …
because of delayed diagnosis and poor prognosis. Malignant cells often reprogram their …
Molecular and clinical activity of CDX-3379, an anti-ErbB3 monoclonal antibody, in head and neck squamous cell carcinoma patients
U Duvvuri, J George, S Kim, D Alvarado… - Clinical Cancer …, 2019 - AACR
Purpose: ErbB3 and its ligand neuregulin-1 (NRG1) are widely expressed in head and neck
squamous cell carcinoma (HNSCC) and associated with tumor progression. A “window-of …
squamous cell carcinoma (HNSCC) and associated with tumor progression. A “window-of …
[HTML][HTML] Window of opportunity trials in head and neck cancer
Head and neck squamous cell carcinoma (HNSCC) has a large global burden of disease
and poor survival outcomes. Recent targeted therapies and immunotherapies have been …
and poor survival outcomes. Recent targeted therapies and immunotherapies have been …
Repurposing of Metformin as a Multifaceted and Multitasking Preventative and Treatment for Cancer
R Chang - Drug Repurposing-Molecular Aspects and …, 2019 - books.google.com
Metformin is a cornerstone treatment of diabetes mellitus. Since 2005 when it has been first
reported to reduce the risk of cancer in diabetics, a large number of preclinical and clinical …
reported to reduce the risk of cancer in diabetics, a large number of preclinical and clinical …
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R Bartrons, H Simon-Molas, A Rodríguez-García… - jdc.jefferson.edu
For a long time, pioneers in the field of cancer cell metabolism, such as Otto Warburg, have
focused on the idea that tumor cells maintain high glycolytic rates even with adequate …
focused on the idea that tumor cells maintain high glycolytic rates even with adequate …
Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”
BLDM Brücher, IS Jamall - 4open, 2019 - 4open-sciences.org
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and
has been associated with a 37% decrease in cancer incidence. While the precise …
has been associated with a 37% decrease in cancer incidence. While the precise …