Neuroimaging and connectomics of drug‐resistant epilepsy at multiple scales: From focal lesions to macroscale networks

S Tavakol, J Royer, AJ Lowe, L Bonilha, JI Tracy… - …, 2019 - Wiley Online Library
Epilepsy is among the most common chronic neurologic disorders, with 30%‐40% of
patients having seizures despite antiepileptic drug treatment. The advent of brain imaging …

Virtual resection predicts surgical outcome for drug-resistant epilepsy

LG Kini, JM Bernabei, F Mikhail, P Hadar, P Shah… - Brain, 2019 - academic.oup.com
Patients with drug-resistant epilepsy often require surgery to become seizure-free. While
laser ablation and implantable stimulation devices have lowered the morbidity of these …

Characterizing the role of the structural connectome in seizure dynamics

P Shah, A Ashourvan, F Mikhail, A Pines, L Kini… - Brain, 2019 - academic.oup.com
How does the human brain's structural scaffold give rise to its intricate functional dynamics?
This is a central question in translational neuroscience that is particularly relevant to …

Prediction of antiepileptic drug treatment outcomes of patients with newly diagnosed epilepsy by machine learning

L Yao, M Cai, Y Chen, C Shen, L Shi, Y Guo - Epilepsy & Behavior, 2019 - Elsevier
Objective The objective of this study was to build a supervised machine learning-based
classifier, which can accurately predict the outcomes of antiepileptic drug (AED) treatment of …

[HTML][HTML] Different patterns of white matter changes after successful surgery of mesial temporal lobe epilepsy

W Li, D An, X Tong, W Liu, F Xiao, J Ren, R Niu… - NeuroImage: Clinical, 2019 - Elsevier
Objectives To explore the dynamic changes of white matters following anterior temporal
lobectomy (ATL) in mesial temporal lobe epilepsy (MTLE) patients who achieved seizure …

[HTML][HTML] Quantification and selection of ictogenic zones in epilepsy surgery

P Laiou, E Avramidis, MA Lopes, E Abela… - Frontiers in …, 2019 - frontiersin.org
Network models of brain dynamics provide valuable insight into the healthy functioning of
the brain and how this breaks down in disease. A pertinent example is the use of network …

Node abnormality predicts seizure outcome and relates to long-term relapse after epilepsy surgery

N Sinha, Y Wang, NM da Silva, A Miserocchi… - bioRxiv, 2019 - biorxiv.org
Objective We assessed pre-operative structural brain networks and clinical characteristics of
patients with drug resistant temporal lobe epilepsy (TLE) to identify correlates of post …

Personalised network modelling in epilepsy

Y Wang, GM Schroeder, N Sinha, PN Taylor - arXiv preprint arXiv …, 2019 - arxiv.org
Epilepsy is a disorder characterised by spontaneous, recurrent seizures. Both local and
network abnormalities have been associated with epilepsy, and the exact processes …

[PDF][PDF] Article type: Critical Review–Invited Commentary

S Tavakol, J Royer, AJ Lowe, L Bonilha, JI Tracy… - minerva-access.unimelb.edu.au
Epilepsy is among the most common chronic neurological disorders with 30-40% of patients
suffering from seizures despite antiepileptic drug treatment. The advent of brain imaging and …

[图书][B] Establishing the Status of White Matter Pathways in Post-Stroke Aphasia and Temporal Lobe Epilepsy Using Anatomical Connectivity Mapping

N Busby - 2019 - search.proquest.com
Since the classical work Wernicke it has been understood that connections in the brain are
important for higher-order behaviours. This disconnection hypothesis has been revisited …