Multiple sclerosis–a review

R Dobson, G Giovannoni - European journal of neurology, 2019 - Wiley Online Library
Multiple sclerosis (MS) is the commonest non‐traumatic disabling disease to affect young
adults. The incidence of MS is increasing worldwide, together with the socioeconomic …

Treatment of multiple sclerosis—success from bench to bedside

M Tintore, A Vidal-Jordana… - Nature Reviews …, 2019 - nature.com
The modern era of multiple sclerosis (MS) treatment began 25 years ago, with the approval
of IFNβ and glatiramer acetate for the treatment of relapsing–remitting MS. Ten years later …

Guidelines on the use of therapeutic apheresis in clinical practice–evidence‐based approach from the Writing Committee of the American Society for Apheresis: the …

A Padmanabhan, L Connelly‐Smith… - Journal of clinical …, 2019 - Wiley Online Library
ABSTRACT The American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA)
Special Issue Writing Committee is charged with reviewing, updating and categorizing …

Reaching an evidence-based prognosis for personalized treatment of multiple sclerosis

D Rotstein, X Montalban - Nature Reviews Neurology, 2019 - nature.com
Personalized treatment is ideal for multiple sclerosis (MS) owing to the heterogeneity of
clinical features, but current knowledge gaps, including validation of biomarkers and …

Early highly effective versus escalation treatment approaches in relapsing multiple sclerosis

D Ontaneda, E Tallantyre, T Kalincik… - The Lancet …, 2019 - thelancet.com
Treatment decisions in multiple sclerosis are complex given the large number of disease-
modifying therapies with diverse safety and efficacy profiles. The importance of early …

Mechanisms of neurodegeneration and axonal dysfunction in progressive multiple sclerosis

J Correale, M Marrodan, MC Ysrraelit - Biomedicines, 2019 - mdpi.com
Multiple Sclerosis (MS) is a major cause of neurological disability, which increases
predominantly during disease progression as a result of cortical and grey matter structures …

An update on vitamin D and disease activity in multiple sclerosis

J Smolders, Ø Torkildsen, W Camu, T Holmøy - CNS drugs, 2019 - Springer
Vitamin D and its main active metabolite 1, 25-dihydroxyvitamin D serve a crucial role in
maintenance of a healthy calcium metabolism, yet have additional roles in immune and …

An argument for broad use of high efficacy treatments in early multiple sclerosis

JM Stankiewicz, HL Weiner - Neurology: Neuroimmunology & …, 2019 - AAN Enterprises
Two different treatment paradigms are most often used in multiple sclerosis (MS). An
escalation or induction approach is considered when treating a patient early in the disease …

Current therapeutic landscape in multiple sclerosis: an evolving treatment paradigm

BAC Cree, J Mares, HP Hartung - Current opinion in neurology, 2019 - journals.lww.com
Current therapeutic landscape in multiple sclerosis: an evol... : Current Opinion in
Neurology Current therapeutic landscape in multiple sclerosis: an evolving treatment …

Dimethyl fumarate: a review in relapsing-remitting MS

HA Blair - Drugs, 2019 - Springer
Dimethyl fumarate (Tecfidera®) is approved for the treatment of relapsing forms of multiple
sclerosis (MS). Based on evidence from the clinical trial and real-world settings, dimethyl …