The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …

BACKGROUND The life of any organism depends on the ability of cells to accurately
recognize and eliminate harmful microbes. To detect the immense repertoire of pathogenic …

The immune system detects disturbances in homeostasis that occur during infection, sterile
tissue damage and cancer. This initiates immune responses that seek to eliminate the …

Systemic lupus erythematosus (SLE) is a severe lifelong multisystem autoimmune disease
characterized by the presence of autoantibodies targeting nuclear autoantigens, increased …

Stimulator of interferon genes (STING) is an adaptor protein that induces the secretion of
type I interferons and proinflammatory cytokines and is triggered by cytosolic DNA of …

Cellular innate immune sensors of DNA are essential for host defense against invading
pathogens. However, the presence of self-DNA inside cells poses a risk of triggering …

Systemic inflammation is central to aging‐related conditions. However, the intrinsic factors
that induce inflammation are not well understood. We previously identified a cell …

Various intracellular pattern recognition receptors (PRRs) recognize cytosolic pathogen-
associated molecular patterns (PAMPs) and damage-associated molecular patterns …

Recognition of foreign nucleic acids is the primary mechanism by which a type I interferon–
mediated antiviral response is triggered. Given that human cells are replete with DNA and …

During viral and bacterial infections, the innate immune system recognizes various types of
pathogen-associated molecular patterns (PAMPs), such as nucleic acids, via a series of …