Abstract Interleukin-21 (IL-21), an autocrine cytokine predominantly produced by follicular
helper T (Tfh) and T helper 17 (Th17) cells, has been proven to play an important role in the …

Psoriasis is an immune mediated inflammatory skin disease with complex etiology involving
interplay between environmental and genetic risk factors as disease initiating event …

The extent to which genetic risk factors are shared between childhood-onset (COA) and
adult-onset (AOA) asthma has not been estimated. On the basis of data from the UK Biobank …

Emerging evidence has suggested that long noncoding RNAs (lncRNA) involved in the
development and progression of cancer. Triple negative breast cancer (TNBC) was an …

The HCP5 RNA gene (NCBI ID: 10866) is located centromeric of the HLA-B gene and
between the MICA and MICB genes within the major histocompatibility complex (MHC) class …

Background Gemcitabine (GEM) is one of the most widely chemotherapy drugs in PC.
However, the chemotherapy resistance always occurs after a period of treatment indicating …

Chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease,
spondyloarthritis and psoriasis cause significant morbidity and are a considerable burden …

Abstract The interleukin (IL)-12/IL-23 pathway is one of many proposed mechanistic
pathways of intestinal inflammation. Earlier studies introduced IL-12 as a major cytokine in …

Objective Psoriatic arthritis (PsA) is a chronic inflammatory arthritis affecting up to 30% of
patients with psoriasis (Ps). To date, most of the known risk loci for PsA are shared with Ps …

Psoriatic arthritis (PsA) is an inflammatory arthritis that manifests in 20–30% of patients
diagnosed with psoriasis. Epidemiologic studies suggest a substantial genetic contribution …