Significant progress has been made in understanding the complex interactions between the
coagulation system and inflammation and autoimmunity. Increased blood-brain-barrier …

To date, the development of disease-modifying therapies for Alzheimer's disease (AD) has
largely focused on the removal of amyloid beta Aβ fragments from the CNS. Proteomic …

Chemotherapeutic agents have been used extensively in breast cancer remedy. However,
most anticancer drugs cannot differentiate between cancer cells and normal cells, leading to …

Proteins containing Ly6/uPAR (LU) domains exhibit very diverse biological functions and
have broad taxonomic distributions in eukaryotes. In general, they adopt a characteristic …

The plasminogen activation (PA) system was originally thought to exclusively promote the
degradation of fibrin by catalyzing the conversion of plasminogen into plasmin via two serine …

The urokinase receptor (uPAR) is a founding member of a small protein family with multiple
Ly6/uPAR (LU) domains. The motif defining these LU domains contains five plesiotypic …

Localized prostate cancer (confined to the gland) generally is considered curable, with
nearly a 100% 5-year-survival rate. When the tumor escapes the prostate capsule, leading …

The aim of this study was to investigate the effect of urokinase-type plasminogen activator
(uPA) on cell viability, apoptosis, and inflammatory cytokine levels in septic human umbilical …

Neurodegenerative disorders and ischemic conditions leading to the development of
Alzheimer's and Parkinson's diseases, vascular dementia, etc. have attracted attention of …

Долгое время внимание исследователей, занимающихся изучением механизмов
нарушений ЦНС, было об ращено на нейродегенеративные процессы и ишемические …