Low-grade inflammation plays a role not only in the pathogenesis of major depressive
disorder (MDD) but probably also in the poor responsiveness to regular antidepressants …

Major depressive disorder (MDD) is a debilitating condition, whose high prevalence and
multisymptomatic nature set its standing as a leading contributor to global disability. To …

Background Treatment-resistant depression (TRD) contributes substantially to the burden of
mood disorders and is undoubtedly an important subpopulation in whom there are clear …

Neuroinflammation is a complex process involved in the physiophatology of many central
nervous system diseases, including addiction. Alcohol abuse is characterized by induction …

Rationale Immune dysfunction has been strongly implicated in the pathophysiology of
bipolar disorder (BD). As such, numerous clinical trials have investigated the effects of anti …

Background Clinical trials of the effects of statins in people with and without depressive
symptoms at baseline have yielded conflicting results with studies reporting both an …

Millions of individuals worldwide suffers from mood disorders, especially major depressive
disorder (MDD), which has a high rate of disease burden in society. Although targeting the …

Abstract Background Systemic sclerosis (SSc) can clinically present with psychological
symptoms, including pain, depression, and distress about disfigurement, physical and social …

Increasingly, clinical research has found inflammatory correlates of psychiatric disorders,
particularly mood symptomatology. Biological measures may provide greater precision in …

Background Compelling evidence links elevated levels of C-reactive protein (CRP) and
other inflammatory markers to poor treatment outcome of antidepressant medication. Little is …