A practical guide to geriatric syndromes in older adults with cancer: a focus on falls, cognition, polypharmacy, and depression
A Magnuson, S Sattar, G Nightingale… - American Society of …, 2019 - ascopubs.org
Geriatric syndromes are multifactorial conditions that are prevalent in older adults. Geriatric
syndromes are believed to develop when an individual experiences accumulated …
syndromes are believed to develop when an individual experiences accumulated …
BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating Wnt/β-catenin signaling
R Zuo, M Liu, Y Wang, J Li, W Wang, J Wu… - Stem cell research & …, 2019 - Springer
Background Radiotherapy to cancer patients is inevitably accompanied by normal tissue
injury, and the bone is one of the most commonly damaged tissues. Damage to bone …
injury, and the bone is one of the most commonly damaged tissues. Damage to bone …
Potential role of senescence in radiation-induced damage of the aged skeleton
Human aging-related changes are exacerbated in cases of disease and cancer, and
conversely aging is a catalyst for the occurrence of disease and multimorbidity. For example …
conversely aging is a catalyst for the occurrence of disease and multimorbidity. For example …
Safety and feasibility of using magnetic resonance imaging criteria to identify patients with “good prognosis” rectal cancer eligible for primary surgery: the phase 2 …
ED Kennedy, M Simunovic, K Jhaveri, R Kirsch… - JAMA …, 2019 - jamanetwork.com
Importance Chemoradiotherapy (CRT), followed by surgery, is the recommended approach
for stage II and III rectal cancer. While CRT decreases the risk of local recurrence, it does not …
for stage II and III rectal cancer. While CRT decreases the risk of local recurrence, it does not …
Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone …
J Song, J Li, F Yang, G Ning, L Zhen, L Wu… - Cell death & …, 2019 - nature.com
Mesenchymal stromal cells (MSCs) can differentiate to various cell types including
osteoblasts, chondrocytes, and adipocytes. This cellular flexibility contributes to widespread …
osteoblasts, chondrocytes, and adipocytes. This cellular flexibility contributes to widespread …
Chronic pain in breast cancer survivors: nociceptive, neuropathic, or central sensitization pain?
L Leysen, N Adriaenssens, J Nijs, R Pas… - Pain …, 2019 - Wiley Online Library
Introduction The differentiation between acute and chronic pain can be insufficient for
appropriate pain management. The aim of this study was to evaluate the prevalence of the …
appropriate pain management. The aim of this study was to evaluate the prevalence of the …
Magnetic resonance imaging radiomic feature analysis of radiation-induced femoral head changes in prostate cancer radiotherapy
Background and Purpose: As a feasible approach, radiotherapy has a great role in prostate
cancer (Pca) management. However, Pca patients have an increased risk of femoral head …
cancer (Pca) management. However, Pca patients have an increased risk of femoral head …
Lowering iron level protects against bone loss in focally irradiated and contralateral femurs through distinct mechanisms
Radiation therapy leads to increased risk of late-onset fragility and bone fracture due to the
loss of bone mass. On the other hand, iron overloading causes osteoporosis by enhancing …
loss of bone mass. On the other hand, iron overloading causes osteoporosis by enhancing …
Effects of ex vivo ionizing radiation on collagen structure and whole-bone mechanical properties of mouse vertebrae
MM Pendleton, SR Emerzian, J Liu, SY Tang… - Bone, 2019 - Elsevier
Bone can become brittle when exposed to ionizing radiation across a wide range of
clinically relevant doses that span from radiotherapy (accumulative 50 Gy) to sterilization …
clinically relevant doses that span from radiotherapy (accumulative 50 Gy) to sterilization …
Irradiation‐induced osteocyte damage promotes HMGB1‐mediated osteoclastogenesis in vitro
F He, J Bai, J Wang, J Zhai, L Tong… - Journal of Cellular …, 2019 - Wiley Online Library
Irradiation‐induced bone loss is widely reported, especially in radiotherapy‐induced
osteoporosis. In addition to the mechanism of osteogenesis inhibition and …
osteoporosis. In addition to the mechanism of osteogenesis inhibition and …