Animal models of hypertension: a scientific statement from the American Heart Association

LO Lerman, TW Kurtz, RM Touyz, DH Ellison… - …, 2019 - Am Heart Assoc
Hypertension is the most common chronic disease in the world, yet the precise cause of
elevated blood pressure often cannot be determined. Animal models have been useful for …

[HTML][HTML] Hypertension associated with fructose and high salt: renal and sympathetic mechanisms

D Komnenov, PE Levanovich, NF Rossi - Nutrients, 2019 - mdpi.com
Hypertension is a leading cause of cardiovascular and chronic renal disease. Despite
multiple important strides that have been made in our understanding of the etiology of …

Identification of new bioactive peptides from Kefir milk through proteopeptidomics: Bioprospection of antihypertensive molecules

FG Amorim, LB Coitinho, AT Dias, AGF Friques… - Food chemistry, 2019 - Elsevier
Kefir, a probiotic beverage prepared from fermented milk, has been associated with
antihypertensive activity. However, the bioactive molecules responsible for this activity still …

Targeting toll‐like receptor 4 signalling pathways: can therapeutics pay the toll for hypertension?

KP Nunes, AA de Oliveira, FE Mowry… - British journal of …, 2019 - Wiley Online Library
The immune system plays a prominent role in the initiation and maintenance of
hypertension. The innate immune system, via toll‐like receptors (TLRs), identifies distinct …

Hypertension and its impact on stroke recovery: from a vascular to a parenchymal overview

B Maïer, N Kubis - Neural plasticity, 2019 - Wiley Online Library
Hypertension is the first modifiable vascular risk factor accounting for 10.4 million deaths
worldwide; it is strongly and independently associated with the risk of stroke and is related to …

Placental nitric oxide formation and endothelium‐dependent vasodilation underlie pravastatin effects against angiogenic imbalance, hypertension in pregnancy and …

JS Chimini, JS Possomato‐Vieira… - Basic & Clinical …, 2019 - Wiley Online Library
Pre‐eclampsia and hypertensive disorders of pregnancy are frequently associated with
foeto‐placental growth restriction, and that may be triggered by angiogenic imbalance and …

[HTML][HTML] Transgenic overexpression of glutathione S-transferase μ-type 1 reduces hypertension and oxidative stress in the stroke-prone spontaneously hypertensive …

E Olson, M Pravenec, V Landa… - Journal of …, 2019 - journals.lww.com
Background: Combined congenic breeding and microarray gene expression profiling
previously identified glutathione S-transferase μ-type 1 (Gstm1) as a positional and …

Renal nerves and leukocyte infiltration in the kidney during salt-sensitive hypertension

AJ Alsheikh, H Lund, JH Dasinger… - American Journal …, 2019 - journals.physiology.org
Based on previous studies suggesting a role of renal nerves in renal inflammation, the
present studies were performed to test the hypothesis that renal nerves mediate renal …

AT1 receptors in the subfornical organ modulate arterial pressure and the baroreflex in two-kidney, one-clip hypertensive rats

NF Rossi, Z Zenner, AK Rishi, E Levi… - American Journal …, 2019 - journals.physiology.org
The subfornical organ (SFO), a forebrain circumventricular organ that lies outside the blood-
brain barrier, has been implicated in arterial pressure and baroreflex responses to …

Renovascular hypertension aggravates atherosclerosis in cholesterol-fed rabbits

Y Chen, AB Waqar, H Yan, Y Wang, J Liang… - Journal of vascular …, 2019 - karger.com
Background: Hypertension is a major risk factor for atherosclerotic disease. However, it is
still not clear whether mechanical stress caused by hypertension directly affects the …